Cluster: Biotechnology

Cluster: Biotechnology

A cluster of topics related to biotechnology.

Biotechnology is the use of technology to modify or manipulate living systems or parts of living systems for the generation of useful products, biological processing, to treat disease or to acquire knowledge. Products manufactured or processed using biotechnology are found in agricultural, pharmaceutical, food, chemical and biofuel industries. Biotechnology is also used in waste treatment.

Biotechnology fundamentals

Biotechnology is used to modify living systems or parts of living systems based on knowledge about essential parts or processes which allow living things to grow, reproduce, use resources and respond to their environment.

  • DNA
  • RNA
  • Transcription
  • Translation
  • Protein
  • Genetics
  • Single Nucleotide Polymorphism (SNP)
  • Genomics
  • Nutritional genomics
  • Proteomics
  • Enzyme
  • Cell
  • Microbiology
  • Metabolism
  • Cellular respiration
  • Phenomics
  • Phosphorylation
  • Kinase
  • DNA methylation
  • DNA methylation landscape
  • Inverton (invertible DNA regions)
  • Aptamer

Biotechnology tools

Biotechnology tools have been developed in research areas such as molecular biology, biochemistry, immunology, genetics, microbiology, cell biology and agriculture.

Nucleic acid sequencing

  • DNA sequencing
  • RNA sequencing
  • Single-cell RNA sequencing (scRNA-seq)
  • amplicon sequencing
  • 16s sequencing
  • 18s sequencing
  • CIDER-Seq

Gene editing tools

Biomaterials

Biomaterials interact with biological systems. They can be natural or synthetic, alive or lifeless and are made of multiple components. Biomaterials are often used in medical applications.

  • Hyaluronic acid
  • Graphene-based biomaterials

Biomolecules

Biomolecules, also called biological molecules, are molecules produced by cells of living organisms. DNA, RNA and enzymes are examples of biomolecules. The following are biomolecules with uses in pharmaceuticals, food, cosmetics or textiles.

  • Hyaluronic acid
  • spider silk, recombinant spider silk is produced by Kraig Biocraft Laboratories
  • Mycotech

Mapping Projects

Mapping projects serve as reference manuals to living systems by showing the organization of components within living organisms. Mapping projects promote the sharing of biological information.

  • Human cell atlas
  • Allen Brain Atlas

Standardization

Facilitating access to DNA sequences

Large biopharmaceutical companies

  • Abbvie
  • Amgen
  • Roche
  • GlaxoSmithKline (GSK)
  • Gilead
  • Novartis
  • Merck
  • Actelion (acquired by Johnson & Johnson)
  • Sanofi
  • Pfizer
  • Adare Pharmaceuticals
  • Genentech
  • Jiangsu Hengrui Medicine

Therapeutics companies

The following companies are using biotechnology in disease research and in development and production of medicine or therapies for a range of injuries or illnesses.

Allergy

Diabetes

Herpes

Software

Drug delivery system

  • Xycrobe Therapeutics
  • Rani Therapeutics
  • Aryx Therapeutics
  • Ablitech, Inc.
  • Abraxis Bioscience
  • ZenCapsule (cancer treatments)
  • Evox Therpeutics (exosome delivery)
  • Anjarium Biosciences (engineered exosomes)
  • Kala Pharmaceuticals (ocular conditions)

Drug discovery platforms

  • AbCellera Biologics
  • Orbit Discovery

Kidney disease

  • Akebia Therapeutics
  • Visterra (antibody-based medicines)

Pain treatment

Dermatology

  • Revance Therapeutics
  • Aclaris Therapeutics
  • Aegle Therapeutics
  • AOBiome

Cancer

  • Argos Therapeutics
  • Circle Pharma
  • Karyopharm Therapeutics
  • Jounce Therapeutics
  • Delve Therapeutics
  • Mersana Therapeutics
  • G1 Therapeutics
  • Stelvio Therapeutics
  • Mirna Therapeutics
  • Stemline Therapeutics
  • Chrysalis Therapeutics
  • CytomX Therapeutics
  • OncoVista Innovative Therapies
  • Iconic Therapeutics
  • Cellerant Therapeutics
  • Sierra Oncology (previously ProNAi Therapeutics)
  • Sorrento Therapeutics
  • IRX Therapeutics
  • Galera Therapeutics
  • Affimed Therapeutics
  • Fate Therapeutics
  • OncoSenX
  • Abraxis Bioscience
  • Simpatica Medicine
  • SF17 Therapeutics
  • Autolus
  • Cell Design Labs
  • iOx Therapeutics
  • Argonaut Therapeutics
  • Genentech
  • Fusion Pharmaceuticals
  • Ziopharm Oncology

Immunotherapy

  • Genocea Bioscience
  • Senti Biosciences
  • Ziopharm Oncology

Rare disease

  • Amicus Therapeutics
  • BioMarin
  • PTC Therapeutics
  • Hyperion Therapeutics
  • Tevard Biosciences
  • Recursion Pharmaceuticals

Therapeutics targeting RNA splicing

  • Envisagenics

Multi-drug resistant bacteria

  • Spero Therapeutics
  • Nabriva Therapeutics
  • Nextbiotics

ADHD treatment

Depression and anxiety

Autoimmune and inflammatory disease

Respiratory and pulmonary disease

Cardiovascular disease

Contract research companies

  • Ichor Therapeutics

Regenerative medicine

Neuromuscular disease

Alzheimer's, neurological and neurodegenerative diseases

  • Rodin Therapeutics
  • Nuon Therapeutics
  • Cognition Therapeutics
  • Voyager Therapeutics
  • Synosia Therapeutics
  • Kernel
  • Renew BioPharma
  • Rheostat Therapeutics
  • Leucadia Therapeutics
  • Alzheon
  • Neuraly
  • BlueRock Therapeutics

Infertility

Contraceptives

Eye disease or injury

  • Loop Therapeutics
  • Oraya Therapeutics
  • Genentech

Bone repair and sports medicine

  • EpiBone
  • Osiris Therapeutics
  • ZetaGen Therapeutics

Eating disorders

Antibacterial products and therapeutics

  • Amprologix
  • Phage therapy
  • Locus Biosciences
  • Eligo Bioscience
  • Nextbiotics
  • Nestle
  • BiomX
  • PhagoMed Biopharma
  • Pherecydes Pharma
  • Procarta Biosystems

Aging

  • Oisin Bio
  • Human Longevity
  • Celgene
  • Unity Biotechnology
  • resTORbio
  • Alkahest
  • Calico

Fibrosis

  • Altay Biopharma

Plant-based manufacturing of therapeutics and vaccines

  • Medicago

Live bacteria therapeutic delivery systems

Genome editing and gene therapy

  • Editas Medicine

Drug discovery in microbes

  • LifeMine Therapeutics
  • Deinove

Vaccines and treatments for infectious disease

  • AbCellera Biologics
  • Clover Biopharmaceuticals
  • Distributed Bio
  • Inovio Pharmaceuticals
  • Meissa Vaccines
  • Microsynbiotix (oral vaccines for aquaculture produced in algae)
  • Moderna
  • Novavax
  • Regeneron
  • Sanofi Pasteur
  • Stemirna Therapeutics
  • Swiftscale Biologics
  • VIR Biotechology
  • Emergex Vaccines Holding Limited
  • Ligandal

Theranostics

Theranostics combines diagnotics and therapeutics.

In vitro diagnostics (IVD) and molecular diagnostics companies

Biotechnology is used by IVD companies to develop tests that detect diseases in vitro, meaning outside the body, from human samples like blood, urine and tissue. Molecular diagnostics are a subset of tests within IVD which detect DNA and RNA in order to assess health. Examples are detection of disease-causing gene mutations or presence of viral DNA or RNA. Detection of proteins using antibodies is considered separate from molecular diagnostics but falls under IVD. In addition to molecular diagnostics and immunoassays, the IVD market also includes clinical chemistry, hematology analyzers and microbiology culture.

  • Mammoth Biosciences
  • Abbott Diagnostics division of Abbott Laboratories
  • Roche Diagnostics
  • Siemens Healthineers
  • Danaher Corporation
  • Bio-Rad Laboratories, Inc.
  • Illumina
  • Thermo Fisher Scientific Inc.
  • LabCorp
  • Luminex Corporation
  • QIAGEN
  • Quest Diagnostics
  • Sysmex Corporation
  • Grail
  • Clear Gene
  • Exosome Diagnostics
  • Cofactor Genomics
  • Owlstone Medical
  • Caspr Biotech
  • Molecular Stethoscope

Diagnostics tools

  • Cas12a based DETECTR system to detect viruses
  • Cas12a based HOMES system to detect viruses and small nucleotide polymorphism sites in human DNA related to health and personal characteristics
  • Cas13a based SHERLOCK to detect pathogenic viruses and bacteria
  • Cas12- and Cas13- based molecular diagnostics by Mammoth Biosciences
  • CRISPR-on-a-chip for cancer diagnostics
  • CRISPR-Chip

Advising oncology treatment based on molecular tests

Personalized health and disease risk testing

Genetic Testing for Disease Risks

  • 23andMe
  • Color Genomics

Epigenetic Testing for Disease Risks

  • Chronomics

Large Genomics and Health Studies

  • Genomes to People

Genomic analysis for drug development and deployment

  • Coral Genomics
  • Auransa
  • Janus Genomics

Microbiome analysis

  • Juno Bio

Proteomics-based biomarkers

  • Inoviv

RNA-based biomarkers

  • Gatehouse Bio

Quantum computing applications in life sciences

  • Entropica Labs
  • GTN Ltd

Genetic ancestry testing

  • 23andMe
  • Ancestry
  • HomeDNA
  • Living DNA
  • Gene-by-Gene provides Family Tree DNA
  • Gene-by-Gene runs the Genographics Project labs which uses the National Geographic Geno DNA Kit
  • African Ancestry
  • Full Genomes
  • DNA Tribes

Imaging technology and bioanalytics

  • Openwater
  • Protea Biosciences Group
  • 3Scan

Bioprinting

  • Vivax Bio and its subsidiary, 3D Bioprinting Solutions

Biotechnology companies that provide research tools

The following companies that produce instruments, kits, reagents and computer software for basic and applied biological research.

  • Merck KGaA
  • Qiagen
  • GenScript
  • Berkeley Lights
  • TouchLight
  • National Institute of Standards and Technology
  • Asimov (Biotechnology)
  • A-Alpha Bio
  • Oxford Genetics
  • SunP Biotech
  • Labcyte
  • Abgent
  • Bento Bioworks developed a portable DNA analysis kit called Bento Lab
  • Refeyn
  • Chai Biotechnologies
  • Arbor Biosciences

Microfluidic cell culture, organ-on-a-chip, human-on-a-chip

  • Scaled Biolabs
  • Hesperos

Sustainable and biodegradable materials

  • bioMASON
  • Bluepha
  • Visolis
  • Kraig Biocraft Laboratories

Food industry

  • Air Protein
  • Amai Proteins
  • Proterro
  • Solar Foods
  • MiProbes (biosensor for food contamination)

Textiles

Chemical industry

  • EnzBond
  • METabolic EXplorer

Agriculture (Ag biotech)

  • Apeel Sciences
  • Monsanto
  • Bayer CropScience
  • DowDuPont
  • Syngenta
  • AquaBounty
  • Caribou Biosciences
  • Benson Hill Biosystems
  • MoA Technology
  • Deinove
  • Pando Nutrition
  • Proterro (feed industry)

Biological control systems

  • Oxitec (insect-based control of disease-carrying mosquitoes and crop-damaging insects)

Carbon capture and conversion

  • Oakbio
  • NovoNutrients

Floriculture

  • Florigene

Biofuels

First generation biofuels include ethanol and plant oil produced from sugar and starch. Second generation biofuels are produced from non-food biomass called lignocellulose and are called cellulosic biofuels. Third generation biofuels are derived from algae and produce feedstock as well as fuel. Fourth generation biofuels are electrofuels or photobiological solar fuels.

  • Proterro

Biomining and bioremediation

  • Bio-Mine
  • Universal Bio Mining

Wetware

  • Grindhouse Wetware
  • Koniku

Biotechnology in conservation

  • Revive & Restore

Skincare products

  • Mother Dirt
  • Deinove

Blockchain and biology

The ability of blockchain to facilitate transparency, control and sharing of information, while keeping data secure, is being applied to biotechnology. Blockchain technology in data storage and online platforms can improve sharing and access to information and also provide quicker ways for tracking and managing various steps in drug development.

 For immunotherapies such as CAR-T cell therapy, blockchain can provide ways to store, maintain, track and secure information about cells derived from a donor patient like editing performed, storage conditions and transport from donor to recipient. Information must be accessible to patients, physicians, laboratory scientists, logistics companies, supply chains and infusion centers.

  • Nebula Genomics (genome sequencing company)
  • Genexi (blockchain and cryptocurrency marketplace)
  • Orvium (scientific publishing)

Other biotechnology companies

  • SyntheX
  • Inscripta

Trade Associations

Biotechnology investment

  • AmorChem
  • Inevitable Ventures
  • Tech.Bio
  • OSI (Oxford Sciences Innovation)
  • Lux Capital

Biotech startup support

  • LabCentral Inc.
  • BioRiiDL
  • Bio, Tech, and Beyond

Consultants in Biotechnology

  • ChinaBio

Research Institutes

Community biolabs and projects

  • BioCurious
  • DIYbio.org
  • Open Insulin

Conferences

  • Transtech Conference
  • International Conference on Biomedical Engineering and Biotechnology
  • Discovery On Target
  • BIO-Europe
  • Biotech Showcase
  • Cell Series USA
  • The American Society of Human Genetics annual meeting
  • The American Society for Cell Biology annual meeting

Biosafety organizations

  • AMEXBIO

Timeline

People

Name
Role
LinkedIn

Further reading

Title
Author
Link
Type
Date

1H 2019 biopharma startup and VC report

Richard Murphey

Web

7/9/2019

Documentaries, videos and podcasts

Title
Date
Link

Companies

Company
CEO
Location
Products/Services

Two Pore Guys, Inc

Santa Cruz, CA

Nanopore Detection Platform

News

Title
Author
Date
Publisher
Description
Press Trust of India
August 24, 2020
@bsindia
A Mission COVID Suraksha has been proposed to be set up with a corpus of nearly Rs 3,000 crore, sources said.
May 22, 2020
news.google.com
Developed by Beijing-based firm, the vaccine shows development of both forms of immunity
April 19, 2020
NDTV.com
The centre has formed a high-level task force to oversee the work being carried out to develop vaccine against COVID-19, which has killed over 500 people in the country.
Rebecca Spalding
October 3, 2019
IN
Biotechnology company ADC Therapeutics SA postponed its planned $200 million (162.34 million pounds) U.S. initial public offering on Wednesday, citing adverse market conditions as it became the third company to pull a planned IPO in recent days.

References

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