Biotechnology is the use of technology to modify or manipulate living systems or parts of living systems for the generation of useful products, biological processing to treat disease or to acquire knowledge. Products manufactured or processed using biotechnology are found in agricultural, pharmaceutical, food, chemical, and biofuel industries. Biotechnology is also used in waste treatment.
Biotechnology is used to modify living systems or parts of living systems based on knowledge about essential parts or processes which allow living things to grow, reproduce, use resources and respond to their environment.
Biotechnology is based on genetics, molecular biology, biochemistry, embryology and cell biology, as well as applied disciplines - chemical and information technology and robotics.
Nucleic acid sequencing Tools
General Biotechnology Tools
Gene editing tools
Biomaterials interact with biological systems. They can be natural or synthetic, alive or lifeless and are made of multiple components. Biomaterials are often used in medical applications.
Biomolecules, also called biological molecules, are molecules produced by cells of living organisms. DNA, RNA and enzymes are examples of biomolecules. The following are biomolecules with uses in pharmaceuticals, food, cosmetics or textiles.
- Hyaluronic acid
- spider silk, recombinant spider silk is produced by Kraig Biocraft Laboratories
Mapping projects serve as reference manuals to living systems by showing the organization of components within living organisms. Mapping projects promote the sharing of biological information and more.
The following companies are using biotechnology in disease research and in development and production of medicine or therapies for a range of injuries or illnesses.
Drug delivery system
Therapeutics targeting RNA splicing
Autoimmune and inflammatory disease
Contract research companies
Alzheimer's, neurological and neurodegenerative diseases
Antibacterial products and therapeutics
Plant-based manufacturing of therapeutics and vaccines
Genome editing and gene therapy
Vaccines and treatments for infectious disease
Biotechnology is used by IVD companies to develop tests that detect diseases in vitro, meaning outside the body, from human samples like blood, urine and tissue. Molecular diagnostics are a subset of tests within IVD which detect DNA and RNA in order to assess health. Examples are detection of disease-causing gene mutations or presence of viral DNA or RNA. Detection of proteins using antibodies is considered separate from molecular diagnostics but falls under IVD. In addition to molecular diagnostics and immunoassays, the IVD market also includes clinical chemistry, hematology analyzers and microbiology culture.
- Cas12a based DETECTR system to detect viruses
- Cas12a based HOMES system to detect viruses and small nucleotide polymorphism sites in human DNA related to health and personal characteristics
- Cas12- and Cas13- based molecular diagnostics by Mammoth Biosciences
- CRISPR-on-a-chip for cancer diagnostics
Genomic analysis for drug development and deployment
The following companies that produce instruments, kits, reagents and computer software for basic and applied biological research.
- Oxitec (insect-based control of disease-carrying mosquitoes and crop-damaging insects)
First generation biofuels include ethanol and plant oil produced from sugar and starch. Second generation biofuels are produced from non-food biomass called lignocellulose and are called cellulosic biofuels. Third generation biofuels are derived from algae and produce feedstock as well as fuel. Fourth generation biofuels are electrofuels or photobiological solar fuels.
Companies in biofuels include Proterro
The ability of blockchain to facilitate transparency, control and sharing of information, while keeping data secure, is being applied to biotechnology. Blockchain technology in data storage and online platforms can improve sharing and access to information and also provide quicker ways for tracking and managing various steps in drug development.
For immunotherapies such as CAR-T cell therapy, blockchain can provide ways to store, maintain, track and secure information about cells derived from a donor patient like editing performed, storage conditions and transport from donor to recipient. Information must be accessible to patients, physicians, laboratory scientists, logistics companies, supply chains and infusion centers.
Some companies at this intersection include:
- Nebula Genomics (genome sequencing company)
- Genexi (blockchain and cryptocurrency marketplace)
- Orvium (scientific publishing)
Consultants in Biotechnology
Groups investing with a focus in
Biotech VC's and companies with biotech focused VC arms
- Transtech Conference
- International Conference on Biomedical Engineering and Biotechnology
- Discovery On Target
- Biotech Showcase
- Cell Series USA
- The American Society of Human Genetics annual meeting
- The American Society for Cell Biology annual meeting
1H 2019 biopharma startup and VC report
A beginner's guide to gene editing - PubMed
Gene Editing on Center Stage - PubMed
How Do Gene Editing Techniques Work?
January 10, 2017
Synthego | Full Stack Genome Engineering
- Synthetic biologySynthetic biology is a multidisciplinary area of research that seeks to create new biological parts, devices, and systems or redesign systems already found in nature to have new abilities.
- CRISPRClustered regularly interspaced short palindromic repeats (CRISPR) is a prokaryotic adaptive immune response that provides immunity against foreign nucleic acids, such as viral DNA and bacterial plasmids, through the use of crRNAs (CRISPR RNAs) and associated Cas genes.
- BiodefenseBiodefense refers to measures to restore biosecurity to a group of organisms who are, or may be, subject to biological threats or infectious diseases.
- BioterrorismBioterrorism is terrorism involving the use of biological weapons.
- Mitsubishi Electric Research Laboratories
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