Human and model organisms
Most biological maps and catalogs allow comparisons between human and non-human model organisms and provide information about homologous genes or corresponding processes across different organisms. Model organisms such as yeast, fruit flies and mice are used in research as a proxy for understanding human biology because they have genes and biological processes in common with humans.
Genomics
- BioCyc - genomes and metabolic pathways, includes EcoCyc
- Dictybase - Dictyostelium discoideum (amoeba)
- DisGeNET
- Dubai Genomics
- ENCODE: Encyclopedia of DNA Elements - NHGRI project building a comprehensive parts list of functional elements in the human genome such as elements that regulate protein and RNA levels
- Flybase
- French Plan for Genomic Medicine 2025
- Repbase - maintained by the Genetic Information Research Institute (GIRI), a collection of eukaryotic genome repeat sequences used for annotation of sequences
- The Literature Human Gene Derived Network
- PomBase - fission yeast Schizosaccharomyces pombe
- WormBase - Caenorhabditis elegans
- Mouse Genome Database (MGD)
- Gene Expression Database (GXD)
- Mouse Models of Human Cancer database (MMHCdb)
Human health and disease relationships to genomics, lifestyle and environment
- All of Us Research Program
- Australian Genomics Health Futures Mission
- Inborn Errors of Metabolism Knowledgebase (IEMbase)
- Initiative on Rare and Undiagnosed Diseases (IRUD) - Japan based program aimed to improve data sharing in relation to clinical diagnostics with genetic analysis
- Personal Genome Project - Harvard PGP, PGP Canada, PGP UK, Genom Austria, PGP China
Phenomics and genotype-phenotype associations
Phenomics is the systematic study of measurable phenotypes or characteristics on a genome-wide scale. Ontologies are used for cataloging the biological roles of gene products using a common language. The characterization of the phenotype of organisms with gene mutations or gene knock outs is used to understand gene function. Both genotype and environment determine phenotype. Since not all genetic differences between individuals have an impact on phenotype, genotype-phenotype association projects aim to catalogue the genotypes that are associated with observable or measurable phenotypes such as disease or altered cell function.
- Chemical Phenomics Initiative - chemotype-phenotype data in zebrafish for drug discovery
- Consortium for Neuropsychiatric Phenomics (CNP)
- The Gene Ontology (GO) resource and GO Consortium - Computational models of biological systems from genes to molecular pathways to organism for the understanding of gene function
- The Knockout Mouse Project
- National Bio Resource Project (NBRP) Rat Phenome
- Navigome
- Phenome Wide Association Studies (PheWAS)
- Phenoscape
Proteins and proteomics
Proteomics is the study of the full protein complement of a cell, tissue or organism. Proteomics and protein databases can be used to map differences in protein composition and shape to health and disease.
- UniProt
- Human Infectious Diseases HPP initiative (HID-HPP) through the Human Proteome Organization (HPO)
Cell, tissue and embryogenesis maps
- Broad Bioimage Benchmark Collection
- Broad Cancer Cell Line Encyclopedia
- Cell Image Library
- Single cell RNA sequencing map of embryogenesis in Xenopus
- Single cell RNA sequencing map of embryogenesis in zebrafish
- Worm Atlas (C. elegans)
Brain and nervous system
Microbiome
- American Gut
Microbes associated with human disease
Animals - Livestock and domesticated
- Functional Annotation of Animal Genomes project (FAANG)
- AgBase - Resource for functional analysis of agricultural plant and animal gene products and Gene Ontology annotations
Dog
Cow
- 1000 Bull Genomes Project
- Bovine Genome Database
Pig
- Pig Genome Database
Animals - Undomesticated
- AgBase - Resource for functional analysis of agricultural plant and animal gene products and Gene Ontology annotations
Plants
- The Arabidopsis Information Resource (TAIR) - database of genetic and molecular biology data for the model higher plant Arabidopsis thaliana
- AgBase - Resource for functional analysis of agricultural plant and animal gene products and Gene Ontology annotations
Phenomics and genotype-phenotype associations
- Australian Plant Phenomics Facility
- The European Infrastructure for Multi-scale Plant Phenomics and Simulation (EMPHASIS)
- International Plant Phenotyping Network
- National Plant Phenomics Centre (IBERS Gogerddan, Wales, UK)
- PHENOME, the French plant phenomic Infrastructure
- Plant Ontology - structured vocabulary and database resource that links plant anatomy, morphology and growth and development to plant genomics data
Bacteria and archaea
Genomics
- BacMap - zoomable and searchable chromosome maps for prokaryotic species (archaebacterial and eubacterial)
Viruses
- Virus-Host DB
Microbiome projects (non human)
- Project Acari - microbiome of ticks
Biodiversity
- The Barcode of Life Data System (BOLD) developed at the Centre for Biodiversity Genomics in Canada
- The Biogeographic Atlas of the Southern Ocean
- International Barcode of Life (iBOL), a research alliance that overseeing BARCODE 500K, BIOSCAN and the Planetary Biodiversity Mission (PBM)
- Map of Life (MOL)
- Ocean Biogeographic Information System (OBIS)
Biological mapping companies
Investors in biological mapping projects
Non-profit support
Other mapping projects
Timeline
People
Further reading
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Documentaries, videos and podcasts
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Companies
References
Contributors
- 1
Meredith Hanel
Medical Genetics PhD, following life science applications that improve the health of humans and our planet. - 2
Carla Faraguna
Golden People and Operations. - 3
Jessica Karpinski
I'm a knowledge seeker with a thirst to understand how the world is connected. - 4
Melanie Manipula
Researcher, writer and a former librarian - 5
Jude Gomila
Founder and CEO of Golden, Entrepreneur. Previously Co Founder of Heyzap. Investor in 100+ companies. Cantabrigian (Gonville and Caius). - 6
Will Suter
Student at the University of Notre Dame looking to expand my knowledge in topics that pique my interest.
