Amgen works in discovery, development and manufacturing of human therapeutics for treatment of illnesses in the areas of oncology, hematology, cardiovascular disease, inflammation, bone health, nephrology and neuroscience.
Amgen’s products include the following: Neulasta (pegfilgrastim); erythropoiesis-stimulating agents (ESAs), such as Aranesp (darbepoetin alfa) and EPOGEN (epoetin alfa); Sensipar/Mimpara (cinacalcet); XGEVA (denosumab); Prolia (denosumab); NEUPOGEN (filgrastim), and other marketed products, such as KYPROLIS (carfilzomib), Vectibix (panitumumab), Nplate (romiplostim), Repatha (evolocumab), BLINCYTO (blinatumomab), IMLYGIC (talimogene laherparepvec) and Corlanor (ivabradine)and Aimovig.
The top protein-based therapeutics include Neulasta, Neupogen, Aranesp, Epogen and Enbrel. ENBREL is on the market in the United States to treat rheumatoid arthritis, plaque psoriasis and psoriatic arthritis. Neulasta treats people receiving chemotherapy to reduce infection. Aranesp and EPOGEN are used to treat anemia in different circumstances including chronic kidney disease. Cinacalcet (Sensipar in US and Mimpara in Europe) is used for secondary hyperparathyroidism with chronic kidney disease. XGEVA is for prevention of skeletal related events in patients with bone metastases from solid tumors. Prolia is used to treat postmenopausal women with osteoporosis at risk of fracture . NEUPOGEN is a recombinant-methionyl human granulocyte colony-stimulating factor (G-CSF) to reduce chance of infection due to low white blood cell count for cancer patients receiving chemotherapy . Aimovig was FDA approved in 2018 and will be marketed in partnership with Novartis as a drug to prevent migraines .
The following Amgen therapeutics are candidates in Phase III clinical trials: Erenumab for episodic migraine; Aranesp for myelodysplastic syndromes; BLINCYTO for acute lymphoblastic leukemia (ALL); ENBREL for psoriatic arthritis and rheumatoid arthritis remission; IMLYGIC for metastatic melanoma; Kyprolis for multiple myeloma; Prolia for glucocorticoid-induced osteoporosis; Repatha for hyperlipidemia; XGEVA for delay or prevention of bone metastases in breast cancer and also for the treatment of cancer-related bone damage in patients with multiple myeloma; Vectibix for metastatic colorectal cancer (mCRC); Omecamtiv mecarbil for chronic heart failure, and EVENITY for postmenopausal osteoporosis and male osteoporosis.
The following Amgen therapeutics are candidates in Phase II clinical trials: BLINCYTO for diffuse Large B-Cell Lymphoma (DLBCL) and relapsed/refractory Philadelphia positive (R/R Ph+) and minimal residual disease of ALL; Erenumab for Chronic migraine; AMG 157 for asthma and atopic dermatitis; AMG 520 for Alzheimer's disease, and AMG 899 for dyslipidemia.
The following Amgen therapeutics are candidates in Phase I clinical trials: IMLYGIC for various cancer types; KYPROLIS for small-cell lung cancer; Oprozomib for multiple myeloma; AMG 176 for various cancer types; AMG 211 for various cancer types; AMG 224 for multiple myeloma, and AMG 301 for migraine. The Company's product candidates in Phase I also include AMG 330 for acute myeloid leukemia; AMG 420 for multiple myeloma; AMG 557 for systemic lupus erythematosus; AMG 570 for systemic lupus erythematosus; AMG 592 for inflammatory diseases; AMG 820 for various cancer types, and AMG 986 for heart failure.
The approved drug Otezla (apremilast), acquired from Celgene in 2019, is a notable therapeutic in Amgen’s autoimmune portfolio. Otezla is for treatment of moderate-to-severe plaque psoriasis and psoriatic arthritis.
Amgen is partnered with EVOQ Therapeutics for license and collaboration to discover and develop drugs for autoimmune disorders.
A biopharmaceutical company focused on discovery and development of small-molecule drugs to treat genetic and rare diseases
miRagen is a clinical stage biopharmaceutical company developing innovative microRNA-targeting therapies to improve human health.
DNA sequencing company specializing in rapid long-read sequencing through nanopores.
Gamida Cell is a biotechnology company developing cell therapies for treating cancer and hematologic diseases.
SiteOne Therapeutics is a Bozeman, Montana-based developer of products for therapeutics and diagnostics.
A biopharmaceutical company focused on the discovery and development of immunotherapy of cancer
A biopharmaceutiical company discovering, developing and manufacturing therapeutics for the treatment of canccer
A company developing technologies in protein-based therapeutics
A biopharmaceutical company focused on the discovery and development of epigenetic medicines to treat cancer and other disease
A biotechnology company developing drugs for the treatment of metabolic diseases, cancer and inflammation
A biopharmaceutical company developing oral therapeutics for the treatment of mineral metabolism and metabolic disorders
A biotechnology company that develops therapeutic antibodies for treating infectious diseases and inflammation
A company that develops therapeutic oral medicines for the treatment of cancer and inflammatory diseases
A company designing bio-therapeutics for endocrine and other disorders
A biotechnology company developing peptides and antibodies for inflammation and autoimmunity
A consulting and research services company for science companies
A biopharmaceutical company developing treatments for neuroendocrine, metabolic and immune disorders
Alexander Julian Veach
Documentaries, videos and podcasts
- CompanyA company, abbreviated 'co.', is a legal entity made up of an association of people, be they natural, legal, or a mixture of both, for carrying on a commercial or industrial enterprise.
- BiopharmaceuticalType of pharmaceutical drug product
- Cluster: BiotechnologyA cluster of topics related to biotechnology.
- Innovative MedicineInnovative Medicine is a company working on advanced integrative and holistic medicine
- Eli LillyUnion army officer, businessman, philanthropist
- Teva Pharmaceutical IndustriesA pharmaceuttical company developing, manufacturing and marketing generic medicines for central nervous system, pain and respiratory conditions