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Regeneron Pharmaceuticals

Regeneron Pharmaceuticals

A biopharmaceutical company developing, manufacturing and commercializing medicines for treating serious medical conditions.

Regeneron discovers, invents, develops, manufactures and commercializes medicines to treat serious medical conditions. The company was founded in 1988, by Eric Shooter, George D. Yancopoulos, and Leonard S. Schleifer (CEO), in Tarrytown, New York, United States.

The company markets medicines for eye diseases, colorectal cancer, allergies, inflammatory disease, metabolic diseases, cardiovascular diseases and infectious diseases. Product candidates in development are in hypercholesterolemia, oncology, rheumatoid arthritis, asthma and atopic dermatitis. Regeneron also develops treatments for viral infections such as those caused by Ebola and coronavirus 2019-nCoV. The coronavirus strain has more recently been renamed SARS-CoV-2 with the disease called COVID-19 (coronavirus disease).

Regeneron developed chimeric genetically engineered mice with fully human immune systems that, when injected with a foreign antigenic substance, will generate human antibodies. The drugs Dupixent and Libtayo are antibodies developed using these mice. Dupixent is a drug for eczema and Libtayo is a cancer immunotherapy.

Ebola

Regeneron used their chimeric mice to develop antibodies against the Ebola virus in 2014 during the outbreak in West Africa. The federal Biomedical Advanced Research and Development Authority (BARDA) supported Regeneron in developing a three-antibody cocktail called EB3 for human testing. EB3 was not used in West Africa as the outbreak subsided in 2015. EB3 was used in a clinical trial in the Democratic Republic of Congo with 65% patients who received a one-time therapy surviving their infections compared to 33% of patients overall.

Coronavirus (SARS-CoV-2/COVID-19)

The company plans to use their chimeric mice to develop a preventative treatment for coronavirus SARS-CoV-2 (previously called 2019-nCoV), which is responsible for an outbreak of the disease COVID-19, declared a global emergency by the World Health Organization (WHO). Regeneron’s team is focused on a region of the virus’s genome the encodes a spike protein, which bypasses cellular defenses in order to infect cells. The team generated a pseudo-virus that couldn’t replicate or cause illness but would mimic the part of 2019-nCoV that penetrates the cell. Immunizing against their spike-coated pseudo-virus generates antibodies that could prevent this strain of coronavirus from getting into cells. The company aims to package a handful of antibodies together as a cocktail with different antibodies binding the same target without competing with each other. This approach will increase the chance of the treatment working as the virus evolves. Regeneron’s SARS-CoV-2 (2019-nCoV) treatment development is supported by BARDA. Two of their neutralizaing antibodies against SARS-CoV-2 are REGN3048 and REGN3051 which bind to S-protein of MERS coronavirus in circulating blood with reduced viral loads in the lungs.

The company is looking to launch clinical trials to explore whether or their arthritis drugs could be repurposed to treat symptoms of novel coronavirus infections. Sanofi and Regeneron are conducting clinical trials for their IL-6 inhibitor antibody called Kevzara (sarilumab), a drug already used to treat rheumatoid arthritis, for treatment of severe cases of COVID-19. The treatment has the potential to calm an overactive immune response.

Products

EYLEA injection – neovascular age related macular degeneration

ARCALYST – Cryoprin-Associated Periodic Syndrome, Familial Cold Auto-inflammatory Syndrome, Muckle-Wells Syndrome

DUPIXENT - Eczema

Kevzara (Sarilumab) - Rheumatoid arthritis

Libtayo - Cancer Immunotherapy

PRALUENT injection – adults with heterozygous familial hypercholesterolemia, clinical atherosclerotic cardiovascular disease

Timeline

1988
Regeneron Pharmaceuticals was founded by Leonard Schleifer.

Products

People

Name
Role
LinkedIn

Adam Escalante

Employee

Adithya Balasubramanian

Employee

Adria Haimann

Employee

Alan LaRotonda

Employee

Alexander Aponte

Employee

Alexander Wong

Employee

Alexandra Garabedian

Employee

Alexia Seebeck

Employee

Alix Walker

Employee

Amy Woodruff

Employee

Andrea Cantor

Employee

Andrea Romero

Employee

Andrew Kang

Employee

Andrew Paetow

Employee

Andy Woodhead

Employee

Anisha Murarka

Employee

Annie Paul, PHR

Employee

Anthony DeBiase

Employee

Arhum Saleem

Employee

Asim Ahmad

Employee

Atul Saxena

Employee

Ben Lubkin

Employee

Benjamin G. Kaplan

Employee

Benjamin Thomson

Employee

Binnur Tuzun Ustun

Employee

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Further reading

Title
Author
Link
Type
Date

Coronavirus outbreak: Top coronavirus drugs and vaccines in development

Web

April 16, 2020

Documentaries, videos and podcasts

Title
Date
Link

Companies

Company
CEO
Location
Products/Services

News

Title
Author
Date
Publisher
Description
Therese Raphael | Bloomberg Opinion
August 27, 2021
@bsindia
Monoclonal antibodies boost immune response to infections by binding to particular sites on the spike protein of the virus that causes Covid-19.
Fraiser Kansteiner
July 16, 2021
FierceBiotech
Regeneron laid plans for a six-year, $1.8 billion expansion at its existing Westchester County campus, according to the New York Governor's office. The expansion will see the company grow its New York headcount by 1,000 over the next five years.
Mark Terry
July 9, 2021
BioSpace
BioSpace's Pharm Country Hotbed ranges from Connecticut, New York, New Jersey, Pennsylvania and Rhode Island.
Regeneron Pharmaceuticals, Inc.
June 28, 2021
www.prnewswire.com:443
/PRNewswire/ -- Regeneron Pharmaceuticals, Inc. (NASDAQ: REGN) and Sanofi today announced that the European Medicines Agency will update the Dupixent®...
Regeneron Pharmaceuticals, Inc.
June 25, 2021
www.prnewswire.com:443
/PRNewswire/ -- Approval based on data from the largest trial to date in patients with advanced basal cell carcinoma previously treated with a hedgehog pathway...
Regeneron Pharmaceuticals, Inc.
June 25, 2021
www.prnewswire.com:443
/PRNewswire/ -- Approval based on a Phase 3 trial demonstrating Libtayo significantly improved overall survival compared to chemotherapy in advanced NSCLC that...
Regeneron Pharmaceuticals, Inc.
June 22, 2021
www.prnewswire.com:443
/PRNewswire/ -- Regeneron Pharmaceuticals, Inc. (NASDAQ: REGN) is scheduled to participate in a virtual fireside chat at the Guggenheim Biopharma Strategy...
Regeneron Pharmaceuticals, Inc.
June 16, 2021
www.prnewswire.com:443
/PRNewswire/ -- UK RECOVERY investigators found REGEN-COV reduced risk of death by 20% in patients hospitalized with COVID-19 who had not mounted their own...
Mark Terry
June 4, 2021
BioSpace
REGEN-COV's 1,200 mg dose is authorized to treat mild-to-moderate COVID-19 in adults and children 12 years and older who weigh 40 kilograms or more.
Regeneron Pharmaceuticals, Inc.
June 4, 2021
www.prnewswire.com:443
/PRNewswire/ -- EUA supported by pivotal Phase 3 data showing 1,200 mg dose reduced risk of hospitalization or death by 70% Only antibody therapy currently...
Regeneron Pharmaceuticals, Inc.
May 25, 2021
www.prnewswire.com:443
/PRNewswire/ -- Regeneron Pharmaceuticals, Inc. (NASDAQ: REGN) will webcast management participation as follows: Bernstein's 37th Annual Strategic Decisions...
Regeneron Pharmaceuticals, Inc.
May 24, 2021
www.prnewswire.com:443
/PRNewswire/ -- Libtayo recommended for approval in the first-line treatment of certain patients with advanced non-small cell lung cancer whose tumors have...
Regeneron Pharmaceuticals, Inc.
May 12, 2021
www.prnewswire.com:443
/PRNewswire/ -- Libtayo is the first immunotherapy to demonstrate an improvement in overall survival in advanced cervical cancer, as well as progression-free...
Regeneron Pharmaceuticals, Inc.
May 6, 2021
www.prnewswire.com:443
/PRNewswire/ -- First quarter 2021 revenues increased 38% to $2.53 billion versus first quarter 2020; revenues excluding REGEN-COVTM(1) increased 20% First...
Heather McKenzie
May 3, 2021
BioSpace
BioSpace takes an in-depth look at the Top 25 of Q1.
Regeneron Pharmaceuticals, Inc.
April 23, 2021
www.prnewswire.com:443
/PRNewswire/ -- Regeneron Pharmaceuticals, Inc. (NASDAQ: REGN) will webcast management participation as follows: Bank of America Securities Virtual Health Care...
Mark Terry
April 19, 2021
BioSpace
It was a particularly busy week for clinical trial news, in part because of several big medical conferences. Here's a look.
Mark Terry
April 12, 2021
BioSpace
Regeneron Pharmaceuticals announced the results from its Phase III trial of recently infected asymptomatic COVID-19 patients for its REGEN-COV (casirivimab with imdevimab) antibody cocktail.
Yasemin Saplakoglu
April 12, 2021
livescience.com
A monoclonal antibody cocktail developed by Regeneron reduced risk of developing symptomatic COVID-19 by 81% in household contacts living with a positive case, company said.
BioSpace
April 12, 2021
BioSpace
Second Phase 3 trial undertaken in collaboration with NIAID to announce results , both using subcutaneous administration of REGEN-COV in asymptomatic individuals without prior COVID-19 infection
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References

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