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US Patent 11428695 Concentration-dependent self-interaction assay

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Is a
Patent
Patent

Patent attributes

Patent Applicant
Regeneron Pharmaceuticals
Regeneron Pharmaceuticals
Current Assignee
Regeneron Pharmaceuticals
Regeneron Pharmaceuticals
Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
Patent Number
11428695
Date of Patent
August 30, 2022
Patent Application Number
16326238
Date Filed
August 18, 2017
Patent Primary Examiner
‌
Tracy Vivlemore
CPC Code
‌
G01N 21/314
‌
G01N 33/6845
‌
G01N 21/77
‌
G01N 33/587

Methods for producing high concentration protein formulations having high stability are provided. Assays for selecting proteins and formulation conditions that have high self-repulsive attributes are used as an early step in the manufacturing process. Specifically, a protein concentration-dependent self-interaction nanoparticle spectroscopy method is employed as a protein colloidal interaction assay.

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