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Distributed Bio

Distributed Bio

A company developing antibody discovery, engineering, informatics tools and services for the life sciences research and drug discovery markets.

An immuno-engineering company providing computational tools and antibody libraries. It has computational platform for analysis and engineering of antibodies, TCRs and peptides and discovery platform of antibody libraries.

Distributed Bio was founded by Jacob Glanville, Giles Day and Chris Smith in 2010. They didn't seek traditional venture capital, but instead built a software platform on Amazon Web Services which allowed people globally to do computational immunology. The company re-incorporated as a California corporation in 2013.

Through the licensing of their software platform, they built cash early to build an antibody discovery and optimization lab. From there Distributed Bio was able to license the data and the ability to engineer new medicines.

Distributed Bio's work on influenza was featured in the 2020 Netflix documentary series "Pandemic: How to Prevent an Outbreak".

Technologies

AbGenesis

AbGenesis was initially built in 2012 and was Distributed Bio's original technology. The AbGenesis repertoire analysis and engineering environment enables analyses of individual cells to millions of B-cell and T-cell receptors, this includes linking of sequence and phenotype data. Users can search sequence data, identify candidate clones, analyze CDR diversity, analyze library selections, analyze hybridoma and immunizationa data, and monitor immune responses.

SuperHuman-2.0

A Johnson & Johnson JLABS resident, Distributed Bio analyzed thousands of human immune systems with its machine learning platform called AbGenesis to have produced the SuperHuman library with 76 billion antibodies, including over 5,000 hits against each of the 26 targets in immuno-oncology and neurodegeneration within Distributed Bio's pipeline.

Pfizer and Boehringer Ingelheim have both licensed Distributed Bio's human monoclonal antibody library SuperHuman 2.0. Charles River partnered with Strategic bio to create an end-to-end platform for therapeutic antibody discovery and development.

The SuperHuman library allows for cross-species coverage, developability profiles for thermostability, aggregation potential and immunogenicity. In October of 2019, Distributed Bio announced the release of SuperHuman 3.0, which is a Single Light Chain (SLiC) library.

Tungsten

Distributed Bio's Tungsten 1.0 is a computationally optimized synthetic single domain library based on camelid repertoire. The library includes a camelid framework for reagent development and a human VH3-23 framework for therapeutic development.

Centivax

Centivax is a universal vaccine technology that has shown promising results in testing against 39 viral strains in influenza including 1918 H1N1 Spanish flu, 1957 H2N2 Asian flu, 1968 H3N2 Hong Kong flu, 1977 H1N1 Russian flu, 2002 H3N2 Fujian flu, and 2009 H1N1 Swine flu.Using Distributed Bio's epitope focusing technology, a Centivax vaccine, is able to focus a subject's immune response against parts of pathogens unable to mutate and induce antibodies directed at those parts. Using pre-2009 viral flu strain information, Centivax was able to neutralize immunity against future pandemic and seasonal viral strains. This is primarily focused on influenza in the animal and human markets, but provides potential for other markets. Distributed Bio is reported to be using this technology to develop a coronavirus vaccine for for the 2019-nCoV outbreak. The coronavirus strain has more recently been renamed SARS-CoV-2 with the disease called COVID-19 (coronavirus disease).

On March 30, 2020, Centivax completed optimization of ultra-potent neutralizing antibodies against SARS-CoV-2.

Tumbler

Tumbler is Distributed Bio's antibody engineering technology which uses artificial intelligence to generate antibodies in greater quantity and shorter time than traditional methods.

Timeline

March 31, 2020

Distributed Bio optimizes anti-SARS protective antibodies to block the novel coronavirus

Since January 25, 2020, a group of Distributed Bio employees has worked to engineer a treatment for the novel COVID-19 coronavirus.

The company's strategy was to engineer a panel of anti-SARS antibodies to make them recognize and block the novel coronavirus. The result of that work is a panel of ultra-high affinity therapeutic antibodies to neutralize SARS-CoV-2 (the virus behind COVID-19). The work leveraged both the Distributed Bio SuperHuman 2.0 human antibody discovery technology and the Tumbler computational antibody optimization technology to discover thousands of antibodies against a novel virus in 9 weeks.

October 11, 2019

Distributed Bio Inc and Good Therapeutics, Inc. Announce Multi-Target Collaboration

October 25, 2018

Charles River and Distributed Bio Enter Exclusive Partnership to Create an Integrated Antibody Discovery and Development Platform

Charles River Laboratories, Inc. announces that it has entered into an exclusive partnership with Distributed Bio, Inc.

April 1, 2013

Distributed Bio was founded by Chris Smith, Jacob Glanville and Giles Day.

People

Name
Role
LinkedIn

Aishani Aatresh

Computational Immunology

Austin Sanchez

Lab Coordinator

Chelsea Jones

Associate Scientist

Chris Smith

Founder and Chief Technology Officer

Christina Pettus, PSM

Scientist

David Gangemi

Director of Virology

David Maurer, PSM

Director of Internal Engineering

Founder and Chief Operations Officer

Founder, Chief Executive Officer and President

Jessica Salas

Associate Scientist

Lilja Klempan

Executive Administrator

Lindsay Blore

Project Manager

Sarah Ives, PSM

Director of Contract Research

Sawsan Youssef, PhD

Chief Science Officer

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Further reading

Title
Author
Link
Type
Date

Call of the wild: A new generation of antibody discovery from human populations

Jacob Glanville, David Louis, David Maurer, Usha Mulvaney, Casey Keyes, Gayathri Shankar, Amy Geurts, Maureen Kagimbi, Distributed Bio

Poster Presentation

Case study on Distributed Bio

Axial

Web

Characterizing heritable variation in the antibody repertoire with NGS, 5' RACE and monozygotic twins

Presentation

June 13, 2012

Combining Superhuman-2.0 and Carterra LSA to realize the dream of a one-week antibody discovery cycle

Yasmina Noubia Abdiche, CSO of Carterra

Presentation

Discovering biologics and biomarkers in the antibody repertoire

Presentation

June 12, 2012

SuperHuman-2.0: How computational immunoengineering can realize the dream of a one-week antibody discovery cycle

Presentation

The Better Biologic: Algorithms, Repertoire, Sequencing, and Synthetic library design

Presentation

2013

Documentaries, videos and podcasts

Title
Date
Link

Distributed Bio

June 9, 2018

Pandemic: How to Prevent an Outbreak

January, 2020

Companies

Company
CEO
Location
Products/Services
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References