Centivax is a therapeutics company founded to treat and eradicate the remaining pathogens of the 21st century. Centivax was spun out of a series of internally incubated technology projects run at Distributed Bio. Centivax and their CEO Jacob Glanville were featured in the Netflix documentary series "Pandemic" talking about their vaccine technology.
Centivax begun at Distributed Bio as a vaccine for mutating and naturally polymorphic pathogens of HIV, influenza, Chagas disease, sleeping sickness, Dengue and Zika. Distributed Bio developed Centivax, an epitope focusing technology which focused the immune response against conserved parts of pathogens that cannot mutate offering a Universal Vaccine design.
In two repeat studies in sus scrofa (pig) in Distributed Bio's animal facility, the epitope focusing vaccine induced antibodies against 39 viral strains of influenza spanning the last century, including all pandemic events (1918 H1N1 Spanish flu, 1957 H2N2 Asian flu, 1968 H3N2 Hong Kong flu, 1977 H1N1 Russian flu, 2002 H3N2 Fujian flu, and 2009 H1N1 Swine flu).
In a Centivax vaccine designed using only pre-2009 viral strain information, the vaccine further elicited broad neutralizing immunity against future pandemic and seasonal viral strains. Observation of an inverse-dose response, single antigen tests, and 159 monoclonal pig antibodies recovered from immunized animals further clarify the mechanism of epitope focusing by Centivax.
Centivax is engineering monoclonal therapeutics against pathogens through computationally guided antibody discovery. This program is part of their response to SARS-CoV-2 (COVID-19) through which they have used the Distributed Bio SuperHuman 2.0 antibody discovery technology and the Tumbler computational antibody optimization technology to discover thousands of antibodies against a novel virus in nine weeks.
Centivax's work in vaccines includes the work done with Distributed Bio on their epitope-focusing technology to guide the immune response against conserved parts of pathogens that cannot mutate. Centivax's flu vaccine is supported by the Bill and Melinda Gates Foundation and featured on Netflix's "Pandemic: How to Prevent an Outbreak".
Centivax's oligoclonals use a mixture of two or more monoclonal antibodies for when multiple proteins need to be targeted such as multiple toxins from a bacteria or in snake venom. Their broad-spectrum antivenom is supported by the National Institutes of Health, through which Centivax is developing a human, broadly neutralizing oligoclonal antivenom. Centivax's antibiotic oligoclonals are supported by MTEC and the NMRC in which they are developing a human, broadly neutralizing oligoclonal antibiotic to neutralize viral factors and toxins secreted by common wounds and sepsis causing bacterium.
Founding Partner, Computational Immunoengineer
Founding Partner and Senior Scientist
Dave Gangemi, PhD
David Tsao, MSc
Founding Partner, COO
Founding Partner, Senior Scientist
Founding Partner, CEO and President
Jean-Philippe Bürckert, PhD
Karina Reyna, MSc
Founding Partner, Lead Veterinarian, Animal Health Care Specialist
Rishi Bedi, MS
Sarah Ives, PSM
Founding Partner, Immune Engineer
Founding Partner, CSO
Shahrad Daraeikia, PSM
Sindy Liao, MSc
Stephanie Wisner, BSc
Operations and Business Development
Founding Partner, herpetologist, venom expert
Valerie Chiou, PSM
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Documentaries, videos and podcasts
COVID-19 Research Update Livestream: Dr. Jacob Glanville and Sarah Ives
April 10, 2020
Searching for the Cure
April 22, 2020
- Cluster: BiotechnologyA cluster of topics related to biotechnology.
- BiotechnologyBiotechnology can refer to the application of science and technology to living organisms or the use of living organisms, their parts, products or models thereof to solve a problem, produce knowledge or produce goods and services. Biotechnology may involve the alteration of living or non-living materials.
- VaccineBiological preparation that improves immunity to a particular disease
- COVID-19COVID-19 is the abbreviated name for coronavirus disease 2019, a respiratory disease caused by a novel coronavirus strain called SARS-CoV-2.
- Cluster: COVID-19A cluster of topics related to COVID-19. COVID-19 is the abbreviated name for coronavirus disease 2019, a respiratory disease caused by a novel coronavirus strain called SARS-CoV-2. COVID-19 was first detected in Wuhan City, China and the outbreak was declared a pandemic on March 11, 2020 by the WHO.