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HIV

HIV

Human immunodeficiency virus (HIV) is a type of retrovirus, that if left untreated can lead to AIDs (Acquired ImmunoDeficiency Syndrome.

Human immunodeficiency virus (HIV) is a type of retrovirus, that if left untreated can lead to AIDs (acquired immunodeficiency syndrome).

HIV is transmitted through bodily fluids that include:

-blood

-semen

-vaginal and rectal fluids

-breast milk

The virus isn’t transferred in air or water, or through casual contact.

Because HIV inserts itself into the DNA of cells, it’s a lifelong condition and currently there’s no drug that eliminates HIV from the body, although many scientists are working to find one.

However, with medical care, including treatment called antiretroviral therapy, it’s possible to manage HIV and live with the virus for many years.

Without treatment, a person with HIV is likely to develop a serious condition called the Acquired Immunodeficiency Syndrome, known as AIDS.

At that point, the immune system is too weak to successfully respond against other diseases, infections, and conditions.

Timeline

September 11, 2019
CRISPR-Edited Stem Cells in a Patient with HIV and Acute Lymphocytic Leukemia

Researchers based in China used CRISPR to edit hematopoietic stem and progenitor cells (HSPCs) to make the gene CCR5 non-functional, which makes cells resistant to HIV-1. The CRISPR-edited CCR5-ablated HSPCs were transplanted into a patient with HIV-1 infection and acute lymphoblastic leukemia, which was in remission. Although there was long-term engraftment of the edited HSPCs, only about 5% of lymphocytes contained the CCR5 disruption.

Further Resources

Title
Author
Link
Type
Date

A Possible Sterilizing Cure of HIV-1 Infection Without Stem Cell Transplantation

Gabriela Turk, Kyra Seiger, Xiaodong Lian, Weiwei Sun, Elizabeth M. Parsons, Ce Gao, Yelizaveta Rassadkina, Maria Laura Polo, Alejandro Czernikier, Yanina Ghiglione, Alejandra Vellicce, Joseph Varriale, Jun Lai, Yuko Yuki, Maureen Martin, Ajantha Rhodes, Sharon R. Lewin, Bruce D. Walker, Mary Carrington, Robert Siliciano, Janet Siliciano, Mathias Lichterfeld, Natalia Laufer, Xu G. Yu

Journal

January 2022

News

Title
Author
Date
Publisher
Description
December 3, 2021
AP NEWS
Here's a look at what The Conversation, a non-profit source of explanatory journalism from experts in academia, is offering today.AP members may find The Conversation content on AP Newsroom or through AP webfeeds.
By EDITH M. LEDERER
December 1, 2021
AP NEWS
UNITED NATIONS (AP) -- Dr. Anthony Fauci, the top U.S. infectious disease expert, said Tuesday the COVID-19 pandemic has diverted scientific and financial resources from the fight against AIDS, seriously impeding global efforts to achieve the U.N.
Paige Minemyer
September 27, 2021
FierceHealthcare
CVS Caremark is expanding its health equity efforts, setting goals that specifically target diseases that disproportionately impact patients of color, such as HIV and sickle cell disease.
Arlene Weintraub
September 27, 2021
FierceBiotech
Researchers led by the City of Hope have developed a novel drug-delivery system that can carry an anti-HIV drug cargo into the brain and other remote tissues in mice, locking the virus into a dormant state. They believe the advance could ultimately be applied to a range of diseases.
Annalee Armstrong
September 17, 2021
FierceBiotech
A CRISPR-Cas9 gene editing technology that has shown promise in clearing HIV from mice is headed into human testing. Excision BioTherapeutics will usher the CRISPR-based therapy EBT-101 into clinical trials after the FDA cleared an investigational new drug application.
SHOW MORE

References

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