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Cepheid Inc

Cepheid Inc

Cepheid Inc. is a Sunnyvale, California-based molecular diagnostics company that looks to provide molecular systems and tests for genetic and organism based diseases.

OverviewStructured DataIssuesContributors

Contents

cepheid.com/us
cepheid.com
Is a
Organization
Organization
Company
Company

Company attributes

Industry
Mpox
Mpox
In-vitro diagnostics (IVD)
In-vitro diagnostics (IVD)
Diagnosis
Diagnosis
Healthcare
Healthcare
Technology
Technology
Biology
Biology
Biotechnology
Biotechnology
...
Location
Sunnyvale, California
Sunnyvale, California
0
San Francisco
San Francisco
B2X
B2B
B2B
CEO
‌
John Bishop
0
Founder
Delphine Suisse Nouvian
Delphine Suisse Nouvian
‌
Kurt Petersen (entrepreneur)
Allen Northrup
Allen Northrup
0
Steve Young
Steve Young
0
‌
Dennis H. Giesing
0
AngelList URL
angel.co/cepheid
Pitchbook URL
pitchbook.com/profiles.../41452-57
Legal Name
Cepheid Inc.
Parent Organization
Danaher Corporation
Danaher Corporation
Number of Employees (Ranges)
5,001 – 10,0000
Email Address
order.management@cepheid.com0
service.agreements@cepheid.com0
techsupport@cepheid.com0
Phone Number
+188883832220
Full Address
904 Caribbean Drive Sunnyvale, CA 94089 United States0
CIK Number
1,037,760
Place of Incorporation
California
California
0
Investors
Biomedical Advanced Research and Development Authority (BARDA)
Biomedical Advanced Research and Development Authority (BARDA)
Innogenetics
Innogenetics
CampVentures
CampVentures
‌
Wheatley Partners
Advanced Technology Ventures
Advanced Technology Ventures
U.S. Department of Defense
U.S. Department of Defense
United States Department of Health and Human Services
United States Department of Health and Human Services
IRS Number
770,441,625
Founded Date
1996
Fax Number
+1-408-541-41920
408-716-25500
+1-408-734-13460
+1-408-716-24420
+1 408-716-2550
Total Funding Amount (USD)
5,200,000
Latest Funding Round Date
January 28, 2013
Competitors
Vela Diagnostics
Vela Diagnostics
BillionToOne
BillionToOne
Stock Symbol
CPHD0
Exchange
Nasdaq
Nasdaq
0
Glassdoor ID
11831
Also Known As
Cepheid
CEPHEID
Patents Assigned (Count)
1
Wellfound ID
cepheid
Country
United States
United States
0
Headquarters
Sunnyvale, California
Sunnyvale, California
0

Other attributes

Company Operating Status
Active
SIC Code
3,826
Wikidata ID
Q15964713

Cepheid Inc. is a molecular diagnostics company that looks to provide molecular systems and tests for genetic-bases diseases as well as organism based diseases. The company was founded by Allen Northrup, Dennis Giesing, and Steve Young, in 1996, in Sunnyvale, California, United States.

The company looks to provide a molecular platform for healthcare leaders, institutions, medical clinics, laboratories, and hospitals. Their tests cover various clinical applications including healthcare-associated infections, sexual health, critical infectious disease, virology, and oncology.

COVID-19

Since the outbreak of COVID-19 (coronavirus), Cepheid has partnered with Sherlock Biosciences to develop a concept project that detects SARS-CoV-2 coronavirus as a first initiative of a broader collaboration to developing molecular diagnostic tests for infectious diseases and oncology. The molecular test will use CRISPR technology and the SHERLOCK platform.

Their collaboration looks to pursue a broad set of solutions for clinical and non-clinical coronavirus solutions. The company looks to deal with infections, critical and non-critical, and oncology that is associated with coronavirus. The company has also partnered with GeneXpert to find solutions for diseases.

On March 21, received emergency use authorization from the FDA for a COVID-19 test. The test is a PCR test that runs in 45 minutes and uses a cartridge and is run on Cepheid’s GeneXpert Systems. The automated systems do not require users to have special training and there is less than a minute of hands on time. There are 23,000 GeneXpert Systems worldwide and 5000 in the US.

Cepheid is an American molecular diagnostics company. Its systems automate traditional nucleic acid tests (tests for specific sequences of DNA or RNA). The tests can be used to identify and analyze pathogens and genetic disorders. Cepheid sells clinical tests for healthcare-associated infections, infectious diseases, sexual health, oncology and genetics.

The cartridges used in Cepheid's testing machines are single-use and must be bought from the manufacturer. The company has been accused of profiteering, particularly in developing countries, by pricing the cartridges at many times the cost of production, and engaging in price discrimination.

System

Cepheid owns the GeneXpert rapid molecular diagnostic system, its main product. The system was developed in the 1990s; the design remained substantially the same from the turn of the century to 2020. Similar tests have subsequently been developed by Abbott and Roche.

The GeneXpert system identifies organisms from their DNA. It extracts genetic material from a sample and, in the case of RNA viruses, it converts the RNA into DNA first. The GeneXpert test is basically an automated version of standard real-time PCR (polymerase chain reaction) amplification and detection.

GeneXpert Systems

GeneXpert Systems

Each sample to be tested is added to a single-use GeneXpert cartridge, sold by Cepheid; after this, the tests are self-contained[6] and fully-automated. The cartridge contains a series of injection-moulded plastic chambers, which hold the chemicals and the sample. To run the test, multiple cartridges are loaded into a desktop machine (also made by Cepheid, but reusable). The sample and chemicals are moved into the test chambers using microfluidics: there is a rotary valve in the center, and some small plungers; the plungers push the sample into the valve, the valve rotates to a new position, and the sample is then pulled out into a new chamber. The machine provides the temperature cycling needed for the PCR (much like a programmable oven). This makes many copies of DNA matching the sample (amplification). Finally, the presences or absence of the pathogen is detected using FISH probes. These are short sections of DNA which have been made to attach to a fluorescent molecule. If the DNA from the sample matches the DNA of the FISH probes, the two bind, and the sample fluoresces. An optical system detects the glow, or its absence. A test for a new disease can be made by simply swapping in a FISH probe that matches the sequence of the new disease.

Tests

Tests for which a GeneXpert cartridge is sold as of 2021 (not exhaustive):

  • influenza
  • respiratory syncytial virus
  • chlamydia and gonorrhea
  • trichomonas vaginalis
  • human papillomavirus
  • group B streptococcus
  • Clostridium difficile
  • enterovirus
  • methicillin-resistant Staphylococcus aureus
  • other drug-resistant bacteria
  • chronic myeloid leukemia
  • clotting disorders
  • HIV
  • hepatitis B
  • hepatitis C
  • SARS-CoV-2

Timeline

No Timeline data yet.

Funding Rounds

Products

Acquisitions

SBIR/STTR Awards

Patents

Further Resources

Title
Author
Link
Type
Date

Cepheid | About Us

https://www.cepheid.com/en_US/about

Web

Cepheid | Enabling Access to Molecular Diagnostic Testing Everywhere

https://www.cepheid.com

Web

Cepheid, Sherlock to Develop Coronavirus Test, Part of Broader MDx Collaboration

https://www.clinicalomics.com/news-and-features/cepheid-sherlock-to-develop-coronavirus-test-part-of-broader-mdx-collaboration/

Web

March 2, 2020

Review of use of a new rapid real-time PCR, the Cepheid GeneXpert® (Xpert) CT/NG assay, for Chlamydia trachomatis and Neisseria gonorrhoeae: result... - PubMed - NCBI

pubmeddev, Gaydos CA

https://www.ncbi.nlm.nih.gov/pubmed/24450867

Web

References

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