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Abalone Bio, Inc uses libraries of yeast cells to experiment and develop their antibody drugs that fight diseases. The company was founded in Richmond, California, United States.
The company looks to grow specific antibodies that can activate or inhibit a drug target(s). The library can utilize gene sequencing, machine learning, and synthetic biology in order to produce recombinant protein versions of the antibodies and determine their efficacy in human cell assays.
Abalone attempts to find antibodies that can bind GPCRs and ion channels that also do more than blocking signals, but also activate targets or that can turn down target activity. They only work with antibodies that survive the biological enrichment processes they put them through and follow the evolution of antibody populations to find usable samples. Generation DNA sequencing is utilized at this step after a computational algorithm can select a "best hit".
The goal of developing these antibodies drugs is to create options for pain, inflammatory diseases, rare cancer, as well as rare kidney diseases.
