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Moderna Therapeutics

Moderna Therapeutics

A biotechnology startup company that develops messenger RNA based therapeutics to treat diseases.

Moderna is focused on developing mRNA-based therapies. Their research works to overcome challenges such as delivery of the mRNA into target tissue and cells, evading the immune system and proper recognition and reading of mRNA messages by ribosomes in the cell. The company uses Amazon’s cloud platform to help speed up the process for getting drugs from research to clinical trials.

COVID-19 response

Moderna has a collaboration with Coalition for Epidemic Preparedness Innovations (CEPI) to produce a vaccine against coronavirus to fight the SARS-CoV-2 (2019-nCoV) outbreak. The coronavirus strain has more recently been renamed SARS-CoV-2 with the disease called COVID-19 (coronavirus disease). That funding will cover manufacturing costs for an mRNA vaccine candidate against the new strain of coronavirus. Preclinical tests and a phase 1 study are planned with supported from federal researchers at the National Institute of Allergy and Infectious Diseases (NIAID). In their approach for SARS-CoV-2 (2019-nCoV), Moderna is using the same technique used to produce a cancer vaccine in 40 days.

Moderna is working with Dr. Barney Graham, deputy director of the Vaccine Research Center at the NIH on SARS-CoV-2 (2019-nCoV) vaccine development. Graham’s research team used sequence information of the 2019-nCoV posted by Chinese scientists on a public database to identify a region of the genetic code to be used to generate a vaccine. The scientists focused on the spike protein, which recognizes receptors or entry points on the host cell. A template for the SARS vaccine was used with the SARS-CoV-2 (2019-nCoV) genetic code swapped in. The sequence was sent to Moderna to make synthetic mRNA for production of protein in order to generate antibodies that target the spike protein.

mRNA-1273 entered Phase I trials on March 3, 2020 and are expected to conclude on June 1, 2021.

On March 16, 2020, the mRNA vaccine called mRNA-1273 began being injected into volunteers in a clinical trial performed by Kaiser Permanente Washington Health Research Institute (KPWHRI).

Timeline

July 26, 2020
Moderna Therapeutics raises a $472,000,000 grant from Biomedical Advanced Research and Development Authority.
April 17, 2020
BARDA commits $483,000,000 in grant funding to Moderna Therapeutics to support its COVID-19 vaccine program.

Biomedical Advanced Research and Development Authority (BARDA), a division of the U.S. Department of Health and Human Services (DHHS) committed $483 million to Moderna Therapeutics as the company moves forward with clinical trials of its vaccine for SARS-CoV-2, the virus which causes COVID-19.

The press release states that under terms of the agreement with BARDA, a division of the Department of Health and Human Services, the cash is expected to fund the advancement of mRNA-1273 to FDA licensure. If the Phase I portion of the study goes well, Moderna is already planning a Phase II in the second quarter of 2020 and a Phase III could begin as early as fall, the company said. BARDA funding will support these late-stage clinical development programs, as well as the scale-up of mRNA-1273 manufacture in 2020 to enable potential pandemic response, Moderna said in a statement.

April 17, 2020
Moderna Therapeutics raises a $483,000,000 grant from Biomedical Advanced Research and Development Authority.
May 3, 2018
Moderna Therapeutics raises a $125,000,000 series H round from Merck KgAa.
February 2018
Moderna Therapeutics raises a $500,000,000 series G round from Abu Dhabi Investment Authority, ArrowMark Partners, BB Biotech, EDBI, Fidelity Management & Research Company, Julius Baer Group, Sequoia Capital China, The Pictet Group and Viking Global Investors.
September 2016
Moderna Therapeutics raises a $8,000,000 grant from Biomedical Advanced Research and Development Authority.
August 2016
Moderna Therapeutics raises a $474,000,000 series F round from AstraZeneca.
January 12, 2016
Moderna Therapeutics raises a $20,000,000 grant from Bill & Melinda Gates Foundation.
2016
Moderna Therapeutics was founded by Derrick Rossi, Kenneth R. Chien, Noubar Afeyan, Robert S. Langer and Timothy A. Springer.
January 5, 2015
Moderna Therapeutics raises a $450,000,000 series E round from Alexion Pharmaceuticals, AstraZeneca, Invus, RA Capital Management, Viking Global Investors and Wellington Management.
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Funding rounds

People

Name
Role
LinkedIn

Aaron Larsen

Employee

aisha s

Employee

Brandi Andreas

Employee

Disha Aggarwal

Employee

Edward Miracco

Investor

Evan Rachlin

Employee

Grace Williams-DuHamel

Employee

Hari Pujar

Employee

Jason Patrick Schrum

Employee

Jervis Nunez, MSCIS

Employee

John Deyrup

Employee

julie oppermann

Employee

Kara Le Fort

Employee

Kari Paisley-Flango

Employee

Lu Bai

Employee

Maja Sedic

Employee

Marianna McGrath

Employee

Nathaniel Reynolds

Employee

Nicolas Preitner

Employee

Nicolette Hruskocy

Employee

Paul Dawson

Employee

Ricardo De Lima

Employee

Scott Canute

Employee

Suhaib Siddiqi

Employee

Teri Doyschen, MBA

Employee

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Further reading

Title
Author
Link
Type
Date

Safety and Immunogenicity Study of 2019-nCoV Vaccine (mRNA-1273) for Prophylaxis SARS CoV-2 Infection (COVID-19) - Full Text View - ClinicalTrials.gov

Web

Documentaries, videos and podcasts

Title
Date
Link

Companies

Company
CEO
Location
Products/Services

News

Title
Author
Date
Publisher
Description
TIMESOFINDIA.COM
June 3, 2021
The Times of India
Here's a quick look at all national, and international vaccines coming our way soon
May 31, 2021
GM Newshub
The world has been grappled with virulent strains of the SARS-COV-2 virus wreaking havoc across the world. From the strain said to have originated in Kent, UK to the much virulent double mutant virus traced in India (and now spreading across the world), mutant strains of the COVID virus are responsible for causing a lot ...
David Rotman
February 5, 2021
MIT Technology Review
New messenger RNA vaccines to fight the coronavirus are based on a technology that could transform medicine. Next up: sickle cell and HIV.
Stephanie Arnett
February 2, 2021
MIT Technology Review
For now, even if you've had covid-19 or been given the shot, it's smart to keep your mask on.
Antonio Regalado
January 14, 2021
MIT Technology Review
Companies and regulators are already laying plans for how to keep up with a changing covid-19 virus.
Zhiyuan Sun
May 22, 2020
The Motley Fool
There are plenty of barriers to overcome before a COVID-19 vaccine can be approved. Does Moderna have the guts to stay the course?
Rowan Walrath
May 12, 2020
AmericanInno
It's part of the company's larger pivot into life sciences.
March 26, 2020
news.google.com
US pharma company Moderna, in collaboration with NIAID, has already started internal safety trial of a vaccine.
Knvul Sheikh and Katie Thomas
January 29, 2020
www.nytimes.com
New technology and better coordination have sped up development. But a coronavirus vaccine is still months -- and most likely years -- away.

References

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