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Moderna Therapeutics

Moderna Therapeutics

A biotechnology startup company that develops messenger RNA based therapeutics to treat diseases

Moderna is focused on developing mRNA-based therapies. Their research works to overcome challenges such as delivery of the mRNA into target tissue and cells, evading the immune system and proper recognition and reading of mRNA messages by ribosomes in the cell. The company uses Amazon’s cloud platform to help speed up the process for getting drugs from research to clinical trials.



Moderna has a collaboration with Coalition for Epidemic Preparedness Innovations (CEPI) to produce a vaccine against coronavirus to fight the SARS-CoV-2 (2019-nCoV) outbreak. The coronavirus strain has more recently been renamed SARS-CoV-2 with the disease called COVID-19 (coronavirus disease). That funding will cover manufacturing costs for an mRNA vaccine candidate against the new strain of coronavirus. Preclinical tests and a phase 1 study are planned with supported from federal researchers at the National Institute of Allergy and Infectious Diseases (NIAID). In their approach for SARS-CoV-2 (2019-nCoV), Moderna is using the same technique used to produce a cancer vaccine in 40 days.



Moderna is working with Dr. Barney Graham, deputy director of the Vaccine Research Center at the NIH on the SARS-CoV-2 (2019-nCoV) vaccine development. Graham’s research team used sequence information of the 2019-nCoV posted by Chinese scientists on a public database to identify a region of the genetic code to be used to generate a vaccine. The scientists focused on the spike protein, which recognizes receptors or entry points on the host cell. A template for the SARS vaccine was used with the SARS-CoV-2 (2019-nCoV) genetic code swapped in. The sequence was sent to Moderna to make synthetic mRNA for production of protein in order to generate antibodies that target the spike protein.

Timeline

February 2018

Moderna Therapeutics raises a $500,000,000 series G round from Viking Global Investors, EDBI, Fidelity Management & Research Company, ArrowMark Partners, Sequoia Capital China, Abu Dhabi Investment Authority, The Pictet Group, Julius Baer Group and BB Biotech.

2010

Moderna Therapeutics was founded.

People

Name
Role
LinkedIn

Aaron Larsen

Employee



aisha s

Employee



Brandi Andreas

Employee



Disha Aggarwal

Employee



Edward Miracco

Investor



Evan Rachlin

Employee



Grace Williams-DuHamel

Employee



Hari Pujar

Employee



Jason Patrick Schrum

Employee



Jervis Nunez, MSCIS

Employee



John Deyrup

Employee



julie oppermann

Employee



Kara Le Fort

Employee



Kari Paisley-Flango

Employee



Lu Bai

Employee



Maja Sedic

Employee



Marianna McGrath

Employee



Nathaniel Reynolds

Employee



Nicolas Preitner

Employee



Nicolette Hruskocy

Employee



Paul Dawson

Employee



Ricardo De Lima

Employee



Scott Canute

Employee



Suhaib Siddiqi

Employee



Teri Doyschen, MBA

Employee



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News

Title
Author
Date
Publisher
Description
Knvul Sheikh and Katie Thomas
January 29, 2020
www.nytimes.com
New technology and better coordination have sped up development. But a coronavirus vaccine is still months -- and most likely years -- away.

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