CRISPR Therapeutics

CRISPR Therapeutics

A biopharmaceutical and gene editing company founded in 2013. CRISPR Therapeutics AG is based in Zug, Switzerland and CRISPR Therapeutics, Inc. is the U.S. subsidiary with R&D operations in Cambridge, Massachusetts and business offices in London, U.K.

CRISPR Therapeutics is a biopharmaceutical and synthetic biology company using genetic engineering to create medical therapies that is headquartered in Zug, Switzerland and was founded in 2013 by Chad Cowan, Craig Mello, Daniel Anderson, Emmanuelle Charpentier, Matthew Porteus, Rodger Novak, and Shaun Foy.

CRISPR Therapeutics is developing medicine for serious diseases using the CRISPR-Cas9 platform that co-founder Emmanuelle Charpentier and Jennifer Doudna co-developed and published together in Science in 2012 . Charpentier and Doudna were awarded the 2015 Breakthrough Prize in Life Sciences. Charpentier is one of the co-founders and is an advisor to CRISPR Therapeutics which was initially called Inception Genomics AG.

CRISPR Therapeutics’ lead product candidate, CTX001, targets sickle cell disease and beta-thalassemia. Cells are harvested from a patient, treated ex vivo with the CRISPR-Cas9-based therapeutic, and returned to the patient. A clinical trial for CTX001 began in December 2017. Other therapeutic developments include CTX101 and other CAR-T therapies to target cancer. CAR-T therapies are chimeric antigen receptor T cell therapies which are immune cells engineered to find and destroy cancer cells. Hemoglobinopathies and regenerative medicine are other areas they are working in.

Partners

Vertex Pharmaceuticals

CRISPR Therapeutics began separate collaborations with Vertex Pharmaceuticals and Bayer in 2015. The joint venture with Bayer has been named Casebia Therapeutics and focuses of blood disorders, blindness and congenital heart disease.

Funding

Series A

On April 20, 2015 CRISPR Therapeutics completed their series A funding round with $35 million in funding from SR One (lead investor), Celgene (lead investor), New Enterprise Associates, Versant Ventures, and Abingworth.

Series B

On June 24, 2016 CRISPR Therapeutics completed their series B funding round with $140 million in funding from New Leaf Venture Partners (lead investor), Franklin Templeton Investments (lead investor), Vertex Pharmaceuticals (lead investor), Bayer Global Investments (lead investor), Wellington Capital Management, Frank Templeton Investments, and Clough Capital Partners.

Timeline

April 2014

CRISPR Therapeutics raises a $25,000,000 series A round from Versant Ventures.

2013

CRISPR Therapeutics was founded by Daniel Anderson, Emmanuelle Charpentier, Rodger Novak, Chad Cowan, Craig Mello, Matthew Porteus and Shaun Foy.

Funding rounds

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People

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Role
LinkedIn

Emmanuelle Chapentier

Co-Founder, Scientific Advisory Board

Michael Tomsicek

CFO

Rodger Novak

Co-Founder and President

Samarth Kulkarni

CEO

Shaun Foy

Co-Founder, former CFO

Further reading

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News

Title
Author
Date
Publisher
Description
Megan Molteni
July 7, 2020
Wired
Tessera Therapeutics is developing a new class of gene editors capable of precisely plugging in long stretches of DNA--something that Crispr can't do.
Nick Paul
June 15, 2020
FierceBiotech
CRISPR Therapeutics and Vertex have presented updated data on the first patients treated with their CRISPR/Cas9 gene-editing therapy. The partners now have evidence that one-time treatment with CTX001 improves outcomes in sickle cell disease and beta thalassemia patients for up to 15 months.
Michael Le Page
June 12, 2020
New Scientist
Two people with beta thalassaemia and one with sickle cell disease no longer need blood transfusions after their blood stem cells were gene edited and put back in their bodies
BioSpace
May 28, 2020
BioSpace
ViaCyte, Inc. , a privately held regenerative medicine company, announced today that ViaCyte's President and CEO Paul Laikind , Ph.D. is scheduled to present at the Jefferies Virtual Healthcare Conference on Thursday, June 4, 2020 at 10 a.m. Eastern Time in Track 9. The company recently announced a $27 million financing to advance
FinSMEs
May 26, 2020
FinSMEs
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References

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