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Bristol-Myers Squibb

Bristol-Myers Squibb

Bristol-Myers Squibb is a large US pharmaceutical company that develops and distributes medicines in the categories of cancer, HIV, analgesics, antibiotics, and cardiology.

Bristol-Myers Squibb Co (BMS) is one of the largest US pharmaceutical companies that manufactures and distributes medicines and drugs against cancer, HIV infection, analgesics, antibiotics and cardiac drugs. Notable BMS pharmaceuticals include Taxol (cancer), Glucophage/metformin hydrochloride (type 2 diabetes), Zerit (HIV/AIDS), and Thalomid/thalidomide (erythema nodosum leprosum, multiple myeloma). The heart medications AVAPRO and PLAVIX were co-developed with Sanofi.

Cancer
Chemotherapy

The National Cancer Institute partnered with BMS in 1991 for the commercial production of plant-based Taxol, using a semisynthetic form of the compound. Taxol was approved in 1992 for treatment of ovarian cancer and in 1994 for treatment of breast cancer.

Immune Checkpoint Inhibitors

BMS developed immune checkpoint inhibitors anti-PD-1, anti-CRLA-4 and anti-LAG-3.

Lymphocyte activation gene-3 (LAG-3) and programmed death-1 (PD-1) are two distinct inhibitory immune checkpoints that are often expressed on tumor-infiltrating lymphocytes, which contribute to tumor-mediated T-cell exhaustion. The antibody combination called Opdualag (nivolumab and relatlimab-rmbw) was FDA approved in March 2022 as treatment for patients with unresectable or metastatic melanoma. Nivolumab is a PD-1 inhibitor, and relatlimab is a LAG-3-blocking antibody, and the combination results in increased T-cell activation compared to either antibody alone.

LAG-3 antibody treatment relatlimab was tested in a phase 3 trial in combination with the PD-1 blocker Opdivo. Data released in March 2022 show that the combination did twice as well as Opdivo alone in slowing cancer progression.

AI and digital pathology

Bristol-Myers Squibb entered collaborations with Roche in March 2022, to support the advancement of two assays for use in clinical trials with the development and deployment of new digital pathology algorithms. The collaboration with Roche Digital Pathology involves creating an AI-based image analysis algorithm to assist pathologists in interpretation of the on-market VENTANA PD-L1 (SP142). VENTANA PD-L1 is an immunohistochemical assay for the assessment of tumor tissue samples to predict patients most likely to respond to specific therapies. BMS will use this algorithm to generate biomarker data from clinical trial samples. The other Roche collaboration involves the Open Environment collaboration with PathAI to integrate a PathAI-developed algorithm for CD8 biomarker analysis into the NAVIFY Digital Pathology workflow software. BMS will use the AI-powered algorithm to analyze clinical trial samples stained with Roche’s CD8 assay and generate spatial biomarker data. Data from both projects aim to improve cancer diagnosis and advance personalized healthcare treatment options.

Timeline

February 14, 2022
Bristol Myers Squibb distrubutes $8M in new grants to improve health equity with a cardiovascular and oncology focus.
May 19, 2021
Bristol Myers Squibb announces a collaboration agreement with Exscientia, an Artificial Intelligence (AI)-focused biopharma company, that could hit $1,200,000,000.
2020
Bristol Myers Squibb acquires MyoKardia.
2019
Bristol-Myers Squibb acquires Celgene.
2009
Bristol-Myser Squibb acquires Medarex.
August 7, 2007
Bristol-Myers Squibb raises a $15,500,000 series C round from Atlas Venture, HBM BioVentures, Polaris Partners and Venrock.
June 26, 2006
Bristol-Myers Squibb raises a $27,000,000 series B round from Atlas Venture, Polaris Partners and Venrock.
2001
DuPont pharmaceuticals is acquired
1989
Bristol-Myers merges with Squibb.
1902
E.R. Squibb & Sons establishes its first quality-control laboratory.

Funding Rounds

Acquisitions

Invested in

Patents

Further Resources

Title
Author
Link
Type
Date

A message of gratitude from BMS

Web

December 6, 2021

Collaborating to Bring CAR T Cell Therapy Science to Patients

Web

June 25, 2021

News

Title
Author
Date
Publisher
Description
May 21, 2021
BioSpace
Bristol Myers Squibb Receives Positive CHMP Opinion Recommending Opdivo (nivolumab) plus Yervoy (ipilimumab) for Treatment of Mismatch Repair Deficient - read this article along with other careers information, tips and advice on BioSpace
May 20, 2021
BioSpace
U.S. Food and Drug Administration Approves Opdivo® (nivolumab) as Adjuvant Treatment of Completely Resected Esophageal or Gastroesophageal Junction Cancer in Patients who have Received Neoadjuvant Chemoradiotherapy - read this article along with other careers information, tips and advice on BioSpace
BioSpace
May 20, 2021
BioSpace
Bristol Myers Squibb (NYSE: BMY) today announced that its Board of Directors has elected Manuel Hidalgo Medina, M.D., Ph.D., to the Board, effective June 1, 2021.
May 19, 2021
BioSpace
Bristol Myers Squibb Announces LAG-3-Blocking Antibody Relatlimab and Nivolumab Fixed-Dose Combination - read this article along with other careers information, tips and advice on BioSpace
DarwinHealth
May 7, 2021
www.prnewswire.com:443
/PRNewswire/ -- DarwinHealth, una empresa de biotecnología con sede en la ciudad de Nueva York, anunció hoy una colaboración en investigación científica con la...
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References

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