Northwestern University

InspireMD, Inc., developer of the CGuardTM Embolic Prevention System for the prevention of stroke caused by the treatment of Carotid Artery Disease, announced it has appointed seasoned marketing executive Kathryn Arnold to its Board of Directors.

American Skin Association has announced the recipients of the 2021 David Martin Carter Mentor Award and the 2021 Research Achievement Awards.

/PRNewswire/ -- American Skin Association (ASA) has announced the recipients of the 2021 David Martin Carter Mentor Award and the 2021 Research Achievement...

Ceyeber Announces Advisory Board of World-Renowned Ophthalmologists - read this article along with other careers information, tips and advice on BioSpace

Verve Therapeutics, a biotech company pioneering a new approach to the care of cardiovascular disease with single-course gene editing medicines, today announced that Sheila Mikhail, J.D., MBA, chief executive officer and co-founder of Asklepios BioPharmaceutical, Inc. (AskBio),

Scientific American is the essential guide to the most awe-inspiring advances in science and technology, explaining how they change our understanding of the world and shape our lives.

Washington [US], April 30 (ANI): During a recent study, researchers from Northwestern University and the University of Hong Kong developed a brain-like computing device that is capable of learning by association.

Cytovia Therapeutics, Inc., a biopharmaceutical company developing allogeneic "off-the-shelf" gene-edited Chimeric Antigen Receptor (CAR)-NK cells derived from induced pluripotent stem cells (iPSCs) and NK cell engager multifunctional antibodies, announced today that Stanley R. Frankel, MD FACP has been appointed as Chief Medical Officer, effective immediately.

New Army-funded synthetic biology research manipulated micro-compartments in cells, potentially enabling bio-manufacturing advances for medicine, protective equipment and engineering applications.

Much of common pharmaceutical development today is the product of laborious cycles of tweaking and optimization. In each drug, a carefully concocted formula of natural and synthetic enzymes and ingredients works together to catalyze a desired reaction. But in early development, much of the process is spent determining what quantities of each enzyme to use to ensure a reaction occurs at a specific speed.

Scientific American is the essential guide to the most awe-inspiring advances in science and technology, explaining how they change our understanding of the world and shape our lives.

Ray et al . (Reports, 14 February 2020, p. 800) report apparent transcriptional circadian rhythms in mouse tissues lacking the core clock component BMAL1. To better understand these surprising results, we reanalyzed the associated data. We were unable to reproduce the original findings, nor could we identify reliably cycling genes. We conclude that there is insufficient evidence to support circadian transcriptional rhythms in the absence of Bmal1 .

The Mediator complex is recruited by transcription factors to all protein-coding genes in eukaryotes and helps to assemble the machinery necessary to transcribe the gene. Abdella et al. present the cryo-electron microscopy structure of the human Mediator-bound preinitiation complex (Med-PIC). The structure shows how Mediator positions the long, flexible C-terminal domain of RNA polymerase II to be phosphorylated by the kinase CDK7, a crucial step for further processing of the RNA into a mature RNA. Most sites where transcription factors bind to Mediator are flexibly tethered to the complex, allowing the large Med-PIC to assemble at any gene. Science , this issue p. [52][1] Eukaryotic transcription requires the assembly of a multisubunit preinitiation complex (PIC) composed of RNA polymerase II (Pol II) and the general transcription factors. The coactivator Mediator is recruited by transcription factors, facilitates the assembly of the PIC, and stimulates phosphorylation of the Pol II C-terminal domain (CTD) by the TFIIH subunit CDK7. Here, we present the cryo-electron microscopy structure of the human Mediator-bound PIC at a resolution below 4 angstroms. Transcription factor binding sites within Mediator are primarily flexibly tethered to the tail module. CDK7 is stabilized by multiple contacts with Mediator. Two binding sites exist for the Pol II CTD, one between the head and middle modules of Mediator and the other in the active site of CDK7, providing structural evidence for Pol II CTD phosphorylation within the Mediator-bound PIC. [1]: /lookup/doi/10.1126/science.abg3074

The team hopes that this work will contribute to the development of treatments for smell dysfunction and loss which has gained special attention in the era of COVID-19.

Being part of competitions with more people increases cheating when there is money to be won, researchers reveal.

Scientists at Northwestern University have developed a novel RNA interference drug that targets the cancer-promoting Bcl2L12 gene in glioblastoma tumors. A new study in a small number of patients showed that it can penetrate the blood-brain barrier.

/PRNewswire/ -- Cheetos is a big winner in strategic ad rankings with its "It Wasn't Me" ad in the 17th consecutive Kellogg School Super Bowl Advertising...

Removing the glass behind the home and visitors' benches in each arena is among the changes the NHL is making to help limit the spread of the coronavirus.

/PRNewswire/ -- Health Alliance Plan, a Michigan-based nonprofit health plan, announced today that it has added five prominent executives to its board of...

/PRNewswire/ -- Universities are facing ever-mounting pressure to address impacts brought on by COVID-19 and the emerging technologies of the Fourth Industrial...