Mosaic Biosciences

Mosaic Biosciences is a biotechnology company based in Colorado producing a new type of synthetic biomaterial based on thiol-ene chemistry to help in drug delivery and native tissue regeneration. The technology is based on thiol-ene click chemistry and modular polymer platform. It is used for drug delivery, regenerative medicine, stem cell therapies, and sealant and adhesion barriers.

The biomaterial developed by Masoaic’s thiol-ene chemistry has many applications while being safe, fast and controllable. It does not react with the body chemistry of the patient, is pH-independent, and not inhibited by oxygen. The non-reactive structure of the biomaterial polymer makes it ideal for drug delivery. Photo-initiation allows for spatial and temporal control of reactions while network structures and material properties can be controlled with the use of click chemistry reactions.

The biomaterials can use or encapsulate proteins, nucleic acids, and cells which makes them act as a bioactive material to initiate a biological response from the body. Mosaic’s technology can use synthetic components like PEG (Polyethylene Glycol) and PLGA (Poly Lactic-co-Glycolic Acid) or natural components like proteins, peptides, hyaluronic acid, and nucleic acids to create biomaterials. The biomaterials created using the technology can have a bioresponsive degradation mechanism and can quickly be cleared from the body.

Pete Mariner founded the company in 2009 and is the Director of Wound Healing as of March 2019. The company’s team primarily consists of polymer chemists, protein and nucleic acid biochemists, and biologists. The company is headquartered in Boulder, Colorado.