MiRXES is a Singapore-headquartered biotech firm with R&D, manufacturing, and clinical lab operations in Singapore, USA, Japan, and China. A molecular diagnostics company, it specializes in microRNA technologies and the development, manufacturing, and provision of diagnostic test kits and clinical services.
MiRXES offers blood tests which use microRNAs - small strands of genetic code found in the bloodstream - as cancer markers. Blood-based microRNAs have, within their genetic code, information about the cancer profiles they carry and therefore have potential to work as a signaler for the presence of different types of cancer.
In February 2020, MiRXES won the rights to manufacture and commercialize the Sars-CoV-2 diagnostic test kits for the novel coronavirus COVID-19. The diagnostic test kit was developed by Singapore's Agency for Science, Technology and Research (A*Star) and Tan Tock Seng Hospital, and has received provisional authorization from the Health Sciences Authority.MiRXES is backed by Singapore-based venture capital firm Venturecraft, which invests in global growth-stage and late-stage ventures in medtech, biotech, and digital health.
Singapore's Health Sciences Authority gave the MiRXES's testing kits provisional approval for use in clinical settings.
The test, called A*STAR Fortitude 2.0, is a real-time PCR assay. Results are generated using a nasopharyngeal swab collected from patients. The product supports the analysis of up to 188 samples per kit.
As of early March 2020, MiRXES has manufactured 100,000 tests in the past few weeks and has shipped around 20,000 tests to local and regional hospitals.
MiRXES has a non-exclusive license to produce the test.
The PCR test was developed in three weeks in collaboration between the Agency for Science, Technology and Research (A*Star) and Tan Tock Seng Hospital, and received approval from the Health Sciences Authority.
The initial batch was manufactured by the Diagnostics Development (DxD) Hub, which also supported the verification of the tests. However, the DxD Hub is now handing the baton off to MiRXES
- MicroRNAMicroRNA (miRNA) refers to small, noncoding RNA molecules that function in regulating the stability or activity of target mRNA transcripts. MiRNAs regulate many biological processes and are dysregulated in disease.
- COVID-19COVID-19 is the abbreviated name for coronavirus disease 2019, a respiratory disease caused by a novel coronavirus strain called SARS-CoV-2. COVID-19 was first detected in Wuhan City, China and the outbreak was declared a pandemic on March 11, 2020 by the World Health Organization.