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eGenesis

eGenesis

eGenesis is a Cambridge, MA - based startup that uses gene editing tech for xenotransplantation procedures in the medical industry.

Overview

eGenesis' stated goal is to make xenotransplantation a routine medical procedure. The company is a Cambridge, MA-based startup that's using the gene-editing tool CRISPR to make pig organs viable for transplants into people.

The company raised $38 million in March 2017 and is cofounded by Harvard geneticist George Church and Luhan Yang. Their research is focusing on removing certain genes in pigs that could cause diseases or organ rejection in humans, making it possible for those pig organs to be transplanted. eGenesis announced in the journal Science that it had produced 37 piglets that had inactivated Porcine Endogenous Retrovirus, or PERV.

In August 2018 eGenesis has disclosed $40m in funding by ARCH Venture Partners, Biomatics Capital Partners, Khosla Ventures, and Fan Ventures.

eGenesis scientists collaborated with scientists at QihanBio in Hangzhou, China on research that combined PERV knockouts with 13 other genetic changes designed to prevent immune rejection. Lead author on the research paper published in 2019 in BioRxriv is Luhan Yang, who is also CEO of QihanBio. Modifications were done in pig ear cells. The pig ear cells were used to generate pig clones. The nuclei of the ear cells, containing the modified DNA, were transferred into eggs from ovaries collected at a slaughterhouse. A second round of editing was used to remove PERV sequences followed by another round of cloning by transferring nuclei to eggs.

Timeline

June 9, 2021
eGenesis appoints Bradford Smith as an independent member of its Board of Directors.
November 5, 2020
eGenesis announces research collaboration with leading academic medical Center.

November 2019
eGenesis raises a $100,000,000 series B round from ARCH Venture Partners, Alta Partners, Bayer, Biomatics Capital Partners, Fresenius Medical Care, Khosla Ventures and Wellington Partners.
March 2017
eGenesis raises a $38,189,826 series A round from ARCH Venture Partners, Alexandria Venture Investments, Alta Partners, Berggruen Holdings, Biomatics Capital Partners, Heritage Provider Network, Khosla Ventures and Uprising.
2015
eGenesis was founded by George Church and Luhan Yang.

Funding Rounds

Patents

Further Resources

Title
Author
Link
Type
Date

Eyeing organs for human transplants, companies unveil the most extensively gene-edited pigs yet

Web

December 19, 2019

News

Title
Author
Date
Publisher
Description
BioSpace
June 9, 2021
BioSpace
eGenesis announced the appointment of accomplished financial executive, Bradford Smith, Chief Financial Officer of Homology Medicines, Inc., as an independent member of the Board of Directors.
June 8, 2021
BioSpace
Aura Biosciences Appoints Sapna Srivastava, Ph.D., to its Board of Directors - read this article along with other careers information, tips and advice on BioSpace
AlleyWatch
March 7, 2021
AlleyWatch
The Pulse of New York Tech
Eudora Wang
March 4, 2021
DealStreetAsia
eGenesis was created in 2015 by George Church and Yang, who also launched China's Qihan Biotech in 2017.
Conor Hale
November 6, 2020
FierceBiotech
EGenesis has announced a research collaboration with Duke University's school of medicine to help develop its xenotransplantation technology into a cell therapy for diabetes.
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References

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