ZenCapsule is a biotechnology company headquartered in Los Angeles, California focused on developing local and targeted delivery of immune checkpoint inhibitors, also known as checkpoint blockade agents.
The binding of immune checkpoint protein receptors, expressed on the surface of cytotoxic T-cells, to their ligands helps cancer cells evade death by cytotoxic T cells, a type of white blood cell that kills cancer cells. Immune checkpoint inhibitors prevent receptor to ligand binding which disrupt signalling and improves survival for adults with solid tumors.
ZenCapsule has a system for conjugating immune checkpoint inhibitors to the surface of platelets, which when infused into patients targets surgical wound sites acting to inhibit tumor recurrence and metastasis. Their formulation can also be delivered to the bone marrow to treat leukemia.
Other ZenCapsule products in development include injectable/sprayable biodegradable gels to control the localized release of immune checkpoint inhibitors and transdermal microneedle patches that can deliver immune checkpoint inhibitors or cancer vaccine antigens for melanoma treatment.
Founder Zhen Gu published in Nature Biomedical Engineering in 2018, a system that tethers platelets carrying a PD-1 antibody, an immune checkpoint inhibitor, to hematopoetic stem cells, which enable the treatment to be delivered to the bone marrow to treat leukemia.
Platelet Immunotherapy Grenades Home In On Leukemia By Riding On Blood Stem Cell Delivery Trucks
- BiotechnologyBiotechnology in a broad sense includes the use of living systems and organisms, as well as their parts for the development or production of products.
- Stem cell technologyTechnology used for isolating, generating, growing and controlling the differentiation of stem cells into specialized cells and the application of stem cell technology for medical and non-medical purposes such as producing meat through cellular agriculture.
- BiotechnologyBiotechnology can refer to the application of science and technology to living organisms or the use of living organisms, their parts, products or models thereof to solve a problem, produce knowledge or produce goods and services. Biotechnology may involve the alteration of living or non-living materials.
- Stem cellStem cells are self-renewing cells that have the potential to become multiple different cell types in the body. Stem cells are found in developing embryos. Adult stem cells maintain and repair tissues throughout life. Induced pluripotent stem cells are a type of stem cell derived from adult cells that are reprogrammed in the lab.