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Pennsylvania State University

Pennsylvania State University

Public university in state college and multiple campuses in pennsylvania, united states

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Margaret M. Luciano
July 8, 2021
Harvard Business Review
Research from first responder incident simulations suggests it's not always a good idea.
Meghan Bartels
June 18, 2021
Young stars can release flares more powerful than our sun's largest on record once a week, according to a massive new analysis of stellar activity.
Science X staff
June 16, 2021
The long relationships between stars and the planets around them--including the Sun and the Earth--may be even more complex than previously thought. This is one conclusion of a new study involving thousands of stars using NASA's Chandra X-ray Observatory.
Asher Y. Rosinger
June 15, 2021
Scientific American
Scientific American is the essential guide to the most awe-inspiring advances in science and technology, explaining how they change our understanding of the world and shape our lives.
May 4, 2021
America's new normal temperature is a degree hotter than it was just two decades ago. Scientists have long talked about climate change -- hotter temperatures...
F.N.B. Corporation
April 29, 2021
/PRNewswire/ -- First National Bank, the largest subsidiary of F.N.B. Corporation (NYSE: FNB), announced that it has promoted Scott Mizerak to Senior Vice...
Chad Hanson
April 16, 2021
Are forest fires a threat to the imperiled Spotted Owl? For years, different groups of scientists assumed so, but a new study turns this assumption on its head. Researchers from the John Muir Project, Pennsylvania State University, and Wild Nature Institute found that these previous studies consistently had a serious methodological flaw: they failed to take into account the impact of post-fire logging on Spotted Owls.
Natalie Wolchover
April 11, 2021
Long-awaited news from Fermilab's Muon g-2 team may resolve a tantalizing conflict between nature and theory. But a separate calculation clouds the picture.
Rebecca Renner
April 11, 2021
Far from a waste of time, daydreaming might be one of the best things you can do with your free time.
Davies, N. G., Abbott, S., Barnard, R. C., Jarvis, C. I., Kucharski, A. J., Munday, J. D., Pearson, C. A. B., Russell, T. W., Tully, D. C., Washburne, A. D., Wenseleers, T., Gimma, A., Waites, W., Wong, K. L. M., van Zandvoort, K., Silverman, J. D., CMMID COVID-19 Working Group, COVID-19 Genomics UK (COG-UK) Consortium, Diaz-Ordaz, K., Keogh, R., Eggo, R. M., Funk, S., Jit, M., Atkins, K. E., Edmunds, W. J.
April 9, 2021
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has the capacity to generate variants with major genomic changes. The UK variant B.1.1.7 (also known as VOC 202012/01) has many mutations that alter virus attachment and entry into human cells. Using a variety of statistical and dynamic modeling approaches, Davies et al. characterized the spread of the B.1.1.7 variant in the United Kingdom. The authors found that the variant is 43 to 90% more transmissible than the predecessor lineage but saw no clear evidence for a change in disease severity, although enhanced transmission will lead to higher incidence and more hospital admissions. Large resurgences of the virus are likely to occur after the easing of control measures, and it may be necessary to greatly accelerate vaccine roll-out to control the epidemic. Science , this issue p. [eabg3055][1] ### INTRODUCTION Several novel variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes COVID-19, emerged in late 2020. One of these, Variant of Concern (VOC) 202012/01 (lineage B.1.1.7), was first detected in southeast England in September 2020 and spread to become the dominant lineage in the United Kingdom in just a few months. B.1.1.7 has since spread to at least 114 countries worldwide. ### RATIONALE The rapid spread of VOC 202012/01 suggests that it transmits more efficiently from person to person than preexisting variants of SARS-CoV-2. This could lead to global surges in COVID-19 hospitalizations and deaths, so there is an urgent need to estimate how much more quickly VOC 202012/01 spreads, whether it is associated with greater or lesser severity of disease, and what control measures might be effective in mitigating its impact. We used social contact and mobility data, as well as demographic indicators linked to SARS-CoV-2 community testing data in England, to assess whether the spread of the new variant may be an artifact of higher baseline transmission rates in certain geographical areas or among specific demographic subpopulations. We then used a series of complementary statistical analyses and mathematical models to estimate the transmissibility of VOC 202012/01 across multiple datasets from the UK, Denmark, Switzerland, and the United States. Finally, we extended a mathematical model that has been extensively used to forecast COVID-19 dynamics in the UK to consider two competing SARS-CoV-2 lineages: VOC 202012/01 and preexisting variants. By fitting this model to a variety of data sources on infections, hospitalizations, and deaths across seven regions of England, we assessed different hypotheses for why the new variant appears to be spreading more quickly, estimated the severity of disease associated with the new variant, and evaluated control measures including vaccination and nonpharmaceutical interventions. Combining multiple lines of evidence allowed us to draw robust inferences. ### RESULTS The rapid spread of VOC 202012/01 is not an artifact of geographical differences in contact behavior and does not substantially differ by age, sex, or socioeconomic stratum. We estimate that the new variant has a 43 to 90% higher reproduction number (range of 95% credible intervals, 38 to 130%) than preexisting variants. Similar increases are observed in Denmark, Switzerland, and the United States. The most parsimonious explanation for this increase in the reproduction number is that people infected with VOC 202012/01 are more infectious than people infected with a preexisting variant, although there is also reasonable support for a longer infectious period and multiple mechanisms may be operating. Our estimates of severity are uncertain and are consistent with anything from a moderate decrease to a moderate increase in severity (e.g., 32% lower to 20% higher odds of death given infection). Nonetheless, our mathematical model, fitted to data up to 24 December 2020, predicted a large surge in COVID-19 cases and deaths in 2021, which has been borne out so far by the observed burden in England up to the end of March 2021. In the absence of stringent nonpharmaceutical interventions and an accelerated vaccine rollout, COVID-19 deaths in the first 6 months of 2021 were projected to exceed those in 2020 in England. ### CONCLUSION More than 98% of positive SARS-CoV-2 infections in England are now due to VOC 202012/01, and the spread of this new variant has led to a surge in COVID-19 cases and deaths. Other countries should prepare for potentially similar outcomes. ![Figure][2] Impact of SARS-CoV-2 Variant of Concern 202012/01. ( A ) Spread of VOC 202012/01 (lineage B.1.1.7) in England. ( B ) The estimated relative transmissibility of VOC 202012/01 (mean and 95% confidence interval) is similar across the United Kingdom as a whole, England, Denmark, Switzerland, and the United States. ( C ) Projected COVID-19 deaths (median and 95% confidence interval) in England, 15 December 2020 to 30 June 2021. Vaccine rollout and control measures help to mitigate the burden of VOC 202012/01. A severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant, VOC 202012/01 (lineage B.1.1.7), emerged in southeast England in September 2020 and is rapidly spreading toward fixation. Using a variety of statistical and dynamic modeling approaches, we estimate that this variant has a 43 to 90% (range of 95% credible intervals, 38 to 130%) higher reproduction number than preexisting variants. A fitted two-strain dynamic transmission model shows that VOC 202012/01 will lead to large resurgences of COVID-19 cases. Without stringent control measures, including limited closure of educational institutions and a greatly accelerated vaccine rollout, COVID-19 hospitalizations and deaths across England in the first 6 months of 2021 were projected to exceed those in 2020. VOC 202012/01 has spread globally and exhibits a similar transmission increase (59 to 74%) in Denmark, Switzerland, and the United States. [1]: /lookup/doi/10.1126/science.abg3055 [2]: pending:yes
Honor Society Foundation
January 11, 2021
/PRNewswire/ -- Honor Society Foundation awarded $58,000 in scholarships to students representing 35 Universities: Highest Honors Student: Kathleen Doherty is...
Dennis Overbye
December 31, 2020
A spooky radio signal showed up after a radio telescope was aimed at the next star over from our sun.
David Cox
December 5, 2020
the Guardian
Illustration by James Melaugh.
David Cox
December 5, 2020
the Guardian
A condition once overlooked by researchers is now in the spotlight as a key symptom of Covid-19
November 24, 2020
Venatorx Pharmaceuticals today announced that Robert Waltermire, Ph.D. has joined the Company as Senior Vice President, Chemistry, Manufacturing and Controls ("CMC").
Joe Pinkstone
November 11, 2020
Mail Online
Researchers found the wrinkle-faced bats in the Costa Rican forest and discovered the males gather in large groups to battle it out among themselves for a mate.
Daniel Cusick
May 26, 2020
Scientific American
Scientific American is the essential guide to the most awe-inspiring advances in science and technology, explaining how they change our understanding of the world and shape our lives.
Kenneth Chang
May 7, 2020
Some researchers hope a decades-old technology might get its moment and be deployed in stores, restaurants and schools.
Ashley Collman
October 23, 2019
Business Insider
Jack Schoenig, a high school senior visiting Penn State from Erie, Pennsylvania, died on Saturday at a house connected to the Chi Phi fraternity.
April 29, 2019
The Hearst Foundations have announced that 76 grants valued at $15,975,000 have been awarded to deserving nonprofit organizations. The Foundations serve as a national philanthropic resource for cultural, educational, health and social service organizations and dedicate millions of dollars in grants quarterly. Their work helps to ensure that people of all backgrounds have the opportunity to build healthy, productive and inspiring lives. This season, Hearst Foundations' grants included a fi...
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