Chimera Bioengineering is a biotechnology company developing cell therapies to treat cancer that is headquartered in South San Francisco, California and was founded in 2015 by Ben Wang, Christina Smolke, and Gusti Zeiner.
The company is researching gene therapeutics based on Chimeric antigen receptor T-cells (CAR-Ts). These reprogrammed immune cells are hot-wired to circumvent immune-evasion. CAR-Ts against leukemias and lymphomas have shown transformative results for patients unresponsive to standard therapy. However limited efficacy against solid tumor cancers, life-threatening toxicities, and limited persistence have stopped these therapies making a wider impact on cancer patients.
Chimera Bioengineering is researching methods to solve the challenges of CAR-Ts with RNA-based gene regulatory systems which allow them to re-program the immune system. They design CAR-T behavior to minimize toxicity, maximize efficacy and extend persistence.
On May 28, 2019 Chimera Bioengineering raised $16.3M in a venture round of funding.
On August 25, 2017 Chimera Bioengineering completed their seed funding round with an undisclosed amount of funding from Kairos Venture Investments.
On November 16, 2016 Chimera Bioengineering raised an undisclosed amount of venture capital funding from The Angel's Forum and Sand Hill Angels.
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- BiotechnologyBiotechnology in a broad sense includes the use of living systems and organisms, as well as their parts for the development or production of products.
- Stem cell technologyTechnology used for isolating, generating, growing and controlling the differentiation of stem cells into specialized cells and the application of stem cell technology for medical and non-medical purposes such as producing meat through cellular agriculture.
- BiotechnologyBiotechnology can refer to the application of science and technology to living organisms or the use of living organisms, their parts, products or models thereof to solve a problem, produce knowledge or produce goods and services. Biotechnology may involve the alteration of living or non-living materials.
- Stem cellStem cells are self-renewing cells that have the potential to become multiple different cell types in the body. Stem cells are found in developing embryos. Adult stem cells maintain and repair tissues throughout life. Induced pluripotent stem cells are a type of stem cell derived from adult cells that are reprogrammed in the lab.