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The company's founder, John Tagg, has conducted research investigating the amount of bacteria present within a diet and their effects on personal hygiene. After contracting rheumatic fever at age 12, Tagg later decided, as a young microbiology student, to seek an effective way of countering the disease. In August 2000, he left his academic position at the University of Otago to launch Blis Technologies. Two years later the first oral probiotic – ThroatGuard, containing BLISK12 – was marketed. A wide variety of products have been subsequently developed, with many now sold internationally in lozenges, gum, powder and other forms.
Blis' products have been sold globally, while the company itself is headquartered in Dunedin, New Zealand. Blis Technologies is publicly listed on the New Zealand Stock Exchange.