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US Patent 12110545 Methods of assessing nuclease cleavage

Patent 12110545 was granted and assigned to Editas Medicine on October, 2024 by the United States Patent and Trademark Office.

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Contents

Is a
Patent
Patent
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Patent attributes

Patent Applicant
Editas Medicine
Editas Medicine
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Current Assignee
Editas Medicine
Editas Medicine
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
121105450
Patent Inventor Names
Dawn Ciulla0
Georgia Giannoukos0
Christopher Wilson0
Date of Patent
October 8, 2024
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Patent Application Number
164758620
Date Filed
January 5, 2018
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Patent Citations
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US Patent 8865406 Engineering and optimization of improved systems, methods and enzyme compositions for sequence manipulation
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US Patent 8871445 CRISPR-Cas component systems, methods and compositions for sequence manipulation
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US Patent 8889356 CRISPR-Cas nickase systems, methods and compositions for sequence manipulation in eukaryotes
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US Patent 8889418 Engineering and optimization of improved systems, methods and enzyme compositions for sequence manipulation
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US Patent 8895308 Engineering and optimization of improved systems, methods and enzyme compositions for sequence manipulation
0
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US Patent 8906616 Engineering of systems, methods and optimized guide compositions for sequence manipulation
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US Patent 8932814 CRISPR-Cas nickase systems, methods and compositions for sequence manipulation in eukaryotes
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US Patent 8945839 CRISPR-Cas systems and methods for altering expression of gene products
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...
Patent Primary Examiner
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Jana A Hines
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CPC Code
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G16B 20/50
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G16B 30/10
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C12Q 1/6869
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Patent abstract

The present disclosure relates to methods of analyzing activity of nucleases, such as ZFNs, TALENs or CRISPR-associated nucleases, in particular their cutting at “off-target” loci.

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