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US Patent 8889356 CRISPR-Cas nickase systems, methods and compositions for sequence manipulation in eukaryotes

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Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Feng Zhang0

Date of Patent

November 18, 2014

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Patent Application Number

141834710

Date Filed

February 18, 2014

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Patent Citations Received

US Patent 12123015 Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

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US Patent 12110545 Methods of assessing nuclease cleavage

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US Patent 12116619 CRISPR mediated in vivo modeling and genetic screening of tumor growth and metastasis

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US Patent 12121524 DNA-PK inhibitors

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US Patent 12123012 Methods and compositions for nucleic acid and protein payload delivery

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US Patent 11760985 CRISPR-Cas complex

US Patent 11773400 Methods for producing genetic modifications in a plant genome without incorporating a selectable transgene marker, and compositions thereof

US Patent 11773403 Methods and materials for high throughput testing of mutagenized allele combinations

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