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US Patent 8945839 CRISPR-Cas systems and methods for altering expression of gene products

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Patent
Patent
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Patent attributes

Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
89458390
Patent Inventor Names
Feng Zhang0
Date of Patent
February 3, 2015
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Patent Application Number
142569120
Date Filed
April 18, 2014
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Patent Citations Received
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US Patent 12123032 CRISPR enzyme mutations reducing off-target effects
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US Patent 12110545 Methods of assessing nuclease cleavage
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US Patent 12116619 CRISPR mediated in vivo modeling and genetic screening of tumor growth and metastasis
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US Patent 12121524 DNA-PK inhibitors
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US Patent 12123015 Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
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US Patent 11661590 Programmable CAS9-recombinase fusion proteins and uses thereof
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US Patent 11667911 Use of exonucleases to improve CRISPR/CAS-mediated genome editing
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US Patent 11674159 Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
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...
Patent Primary Examiner
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Anne Gussow
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Patent abstract

The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for utilizing the CRISPR-Cas system.

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