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US Patent 10274486 System, device and method for high-throughput multi-plexed detection

Patent 10274486 was granted and assigned to Yale University on April, 2019 by the United States Patent and Trademark Office.

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Patent
Patent

Patent attributes

Patent Applicant
Yale University
Yale University
Current Assignee
Yale University
Yale University
Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
Patent Number
10274486
Date of Patent
April 30, 2019
Patent Application Number
15290874
Date Filed
October 11, 2016
Patent Citations Received
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US Patent 12105086 System, device and method for high-throughput multi-plexed detection
0
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US Patent 11513076 Single molecule detection or quantification using DNA nanotechnology
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US Patent 11753743 High-throughput single-cell polyomics
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US Patent 11353448 Methods and compositions for quantifying metabolites and proteins from single cells
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US Patent 11493508 Compositions and methods for the simultaneous genomic, transcriptomic and proteomic analysis of single cells
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US Patent 11525783 Systems, devices and methods for cell capture and methods of manufacture thereof
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US Patent 10983116 System, device and method for high-throughput multi-plexed detection
‌
US Patent 11066689 Analysis and screening of cell secretion profiles
...
Patent Primary Examiner
‌
Changhwa J Cheu
Patent abstract

The present invention relates to a system, device, and method for the high throughput multiplexed detection of a wide number of compounds. The invention comprises of a microwell array coupled to a capture agent array to form a plurality of interfaces between a microwell and a set of immobilized capture agents. The set of capture agents comprises a plurality of distinguishable features, with each feature corresponding to the detection of a particular compound of interest. In certain embodiments, each microwell is configured to contain a single cell. The invention is therefore capable of performing a high throughput analysis of single cell profiles, including profiles of secreted compounds.

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