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US Patent 12105086 System, device and method for high-throughput multi-plexed detection

Patent 12105086 was granted and assigned to Yale University on October, 2024 by the United States Patent and Trademark Office.

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Contents

Patent abstractTimelineTable: Further ResourcesReferences
Is a
Patent
Patent
1

Patent attributes

Patent Applicant
Yale University
Yale University
1
Current Assignee
Yale University
Yale University
1
Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
1
Patent Number
121050861
Patent Inventor Names
Jonathan Chen1
Yao Lu1
Rong Fan1
Date of Patent
October 1, 2024
1
Patent Application Number
172042791
Date Filed
March 17, 2021
1
Patent Citations
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US Patent 8460878 Methods and arrays for detecting cells and cellular components in small defined volumes
1
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US Patent 8492165 Microfluidic interface
1
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US Patent 8865479 Screening assays and methods
1
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US Patent 9188586 System, device and method for high-throughput multi-plexed detection
1
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US Patent 9506917 System, device and method for high-throughput multi-plexed detection
1
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US Patent 10274486 System, device and method for high-throughput multi-plexed detection
1
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US Patent 10584366 Analysis and screening of cell secretion profiles
1
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US Patent 10983116 System, device and method for high-throughput multi-plexed detection
1
...
Patent Primary Examiner
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Changhwa J Cheu
1
CPC Code
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G01N 2570/00
1
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G01N 33/54386
1
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G01N 33/54306
1
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G01N 33/54366
1
Patent abstract

The present invention relates to a system, device, and method for the high throughput multiplexed detection of a wide number of compounds. The invention comprises of a microwell array coupled to a capture agent array to form a plurality of interfaces between a microwell and a set of immobilized capture agents. The set of capture agents comprises a plurality of distinguishable features, with each feature corresponding to the detection of a particular compound of interest. In certain embodiments, each microwell is configured to contain a single cell. The invention is therefore capable of performing a high throughput analysis of single cell profiles, including profiles of secreted compounds.

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