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US Patent 10071979 Process of producing cycloalkylcarboxamido-indole compounds

Patent 10071979 was granted and assigned to Vertex Pharmaceuticals on September, 2018 by the United States Patent and Trademark Office.

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Patent Citations Received
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US Patent 12065432 Solid forms of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl) benzoic acid
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Patent abstract

The present invention features processes for preparing compounds, such as (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide (Compound 1), useful for treating CFTR mediated diseases such as cystic fibrosis.

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Patent Inventor Names
Benjamin Joseph Littler0
Cristian Harrison0
Daniel T. Belmont0
David Andrew Siesel0
Elaine Chungmin Lee0
Gerald J. Tanoury0
Peter Jamison Rose0
Robert Michael Hughes0
William A. Nugent0
Young Chun Jung0
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Patent Citations Received
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US Patent 11752106 Pharmaceutical composition and administrations thereof
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US Patent 11639347 Modulators of ATP-binding cassette transporters
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Infobox
Is a
Patent
Patent
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Patent Applicant
Vertex Pharmaceuticals
Vertex Pharmaceuticals
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Current Assignee
Vertex Pharmaceuticals
Vertex Pharmaceuticals
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
100719790
Date of Patent
September 11, 2018
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Patent Application Number
146872860
Date Filed
April 15, 2015
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Patent Citations Received
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US Patent 10231932 Process of preparing pharmaceutical compositions for the treatment of CFTR mediated diseases
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US Patent 10239867 Modulators of ATP-binding cassette transporters
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US Patent 10537565 Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
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US Patent 10597384 Solid forms of 3-(6-(1-(2,2-difluorobenzo[D][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl) benzoic acid
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US Patent 10626111 Modulators of ATP-binding cassette transporters
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US Patent 10646481 Pharmaceutical composition and administrations thereof
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US Patent 10662192 Modulators of ATP-binding cassette transporters
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US Patent 10738036 Deuterated CFTR modulators
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US Patent 10875846 Processes for the preparation of Tezacaftor and intermediates thereof
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US Patent 10906891 Solid forms of (R)-1(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide
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US Patent 10975061 Modulators of ATP-binding cassette transporters
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US Patent 10980746 Pharmaceutical compositions for the treatment of cystic fibrosis transmembrane conductance regulator mediated diseases
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US Patent 10987348 Modulators of ATP-binding cassette transporters
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US Patent 11052075 Pharmaceutical compositions of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl) benzoic acid and administration thereof
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US Patent 11291662 Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
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US Patent 11564916 Pharmaceutical composition and administrations thereof
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US Patent 11578062 Solid forms of (R)-1(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide
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Patent Primary Examiner
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Nyeemah A Grazier
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Patent Citations Received
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US Patent 10738036 Deuterated CFTR modulators
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US Patent 11564916 Pharmaceutical composition and administrations thereof
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