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US Patent 10071979 Process of producing cycloalkylcarboxamido-indole compounds

Patent 10071979 was granted and assigned to Vertex Pharmaceuticals on September, 2018 by the United States Patent and Trademark Office.

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Is a

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Patent attributes

Patent Applicant

Vertex Pharmaceuticals

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Current Assignee

Vertex Pharmaceuticals

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Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Daniel T. Belmont0

Young Chun Jung0

Benjamin Joseph Littler0

Cristian Harrison0

David Andrew Siesel0

Elaine Chungmin Lee0

Gerald J. Tanoury0

Peter Jamison Rose0

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Date of Patent

September 11, 2018

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Patent Application Number

146872860

Date Filed

April 15, 2015

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Patent Citations Received

US Patent 12065432 Solid forms of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl) benzoic acid

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US Patent 10738036 Deuterated CFTR modulators

US Patent 11564916 Pharmaceutical composition and administrations thereof

US Patent 10875846 Processes for the preparation of Tezacaftor and intermediates thereof

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US Patent 10906891 Solid forms of (R)-1(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide

US Patent 11578062 Solid forms of (R)-1(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide

US Patent 10975061 Modulators of ATP-binding cassette transporters

US Patent 10980746 Pharmaceutical compositions for the treatment of cystic fibrosis transmembrane conductance regulator mediated diseases

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Patent Primary Examiner

Nyeemah A Grazier

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Patent abstract

The present invention features processes for preparing compounds, such as (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide (Compound 1), useful for treating CFTR mediated diseases such as cystic fibrosis.

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