CytomX Therapeutics is a privately funded and publicly traded biotechnology company based in the South San Francisco, California and was founded in 2008 by Fred Gluck and Patrick Daugherty. It is a clinical stage oncology-focused biopharmaceutical company pioneering in a novel class of investigational antibody therapeutics based on its Probody therapeutic technology platform.
Probody therapeutics are designed to exploit unique conditions of the tumor microenvironment to more effectively localize antibody binding and activity while limiting activity in healthy tissues. CytomX's product pipeline includes cancer immunotherapies against clinically-validated targets. CX-072 and CX-188 are PD-L1 targeting Probody therapeutic. CX-2009 is an in-class Probody drug conjugate targeting CD166. All three are owned wholly by CytomX.
The company is also collaborating with other biopharmaceutical companies including AbbVie, Amgen, Bristol-Myers Squibb Company, and ImmunoGen, Inc. BMS-986249 is a CTLA-4 targeting Probody therapeutic partnered with Bristol Myers Squibb. CX-2029 is a DC71 targeting Probody drug conjugate partnered with AbbVie.
All products, except CX-188 are in various Phase 1/2 clinical trial progression. CX-2009 is currently being evaluated in its clinical trial, while CX-2009 and BMS-986249 are enrolling patients for the clinical studies.
Timeline
Funding rounds
People
Alison Joly
Senior VP, Program and Alliance Management
Charles S. Fuchs
Director
Danielle Olander
Senior VP, Talent and Administrative Operations
Debanjan Ray
CFO
Eric Kanowsky
Investor
Fred Gluck
Co-Founder & Director
George Holbrook
Investor
Hoyoung Huh
Chairman
Jim West
Employee
John Petote
Investor
John Scarlett
Director
Lloyd A. Rowland, Jr.
Senior VP, General Counsel, Secretary, & Chief Compliance Officer
Matthew Young
Director
Mike Panesis
Investor
Olga Vasiljeva
Employee
Patrick Daugherty
Founder
Rachel Humphrey
Chief Medical Officer
Sean A. McCarthy
President & CEO
Sridhar Viswanathan
Senior VP, Process Sciences and Manufacturing Operations
W. Michael Kavanaugh
Chief Scientific Officer & Head of Research and Non-Clinical Development
Further reading
CytomX Therapeutics Announces Senior Management Appointments
CytomX Therapeutics Inc.
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