Broad Institute

Broad Institute

Broad Institute is a biomedical and genomic research center.

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Documentaries, videos and podcasts





April 30, 2021
A new study is drawing the most detailed picture yet of SARS-CoV-2 infection in the lung, revealing mechanisms that result in lethal COVID-19, and may explain long-term complications and show how COVID-19 differs from other infectious diseases. Led by researchers at Columbia University Vagelos College of Physicians and Surgeons and Herbert Irving Comprehensive Cancer Center, the study found that in patients who died of the infection, COVID-19 unleashed a detrimental trifecta of runaway...
Stephanie M. McPherson
April 30, 2021
Scientists from several hospitals and research centers have shown what happens in individual cells of patients who died of COVID-19. In a study published in Nature, the researchers describe how infected cells from multiple organs exhibited a range of molecular and genomic changes. They also saw signs of multiple, unsuccessful attempts of the lungs to repair themselves in response to respiratory failure, which is the leading cause of death in COVID-19 patients.
Brian Cleary
April 15, 2021
Nature Biotechnology
Recent methods for spatial imaging of tissue samples can identify up to ~100 individual proteins1-3 or RNAs4-10 at single-cell resolution. However, the number of proteins or genes that can be studied in these approaches is limited by long imaging times. Here we introduce Composite In Situ Imaging (CISI), a method that leverages structure in gene expression across both cells and tissues to limit the number of imaging cycles needed to obtain spatially resolved gene expression maps. CISI defines gene modules that can be detected using composite measurements from imaging probes for subsets of genes. The data are then decompressed to recover expression values for individual genes. CISI further reduces imaging time by not relying on spot-level resolution, enabling lower magnification acquisition, and is overall about 500-fold more efficient than current methods. Applying CISI to 12 mouse brain sections, we accurately recovered the spatial abundance of 37 individual genes from 11 composite measurements covering 180 mm2 and 476,276 cells. Spatial transcriptomics is enhanced by using imaging probes for subsets of genes.
Conor Hale
March 26, 2021
The Broad Institute of MIT and Harvard has launched a new, major initiative to support machine-learning-powered research into the life sciences.
March 25, 2021
Former Google CEO Eric Schmidt and his wife, Wendy, have given $150 million to a research institute to establish a "new era of biology" aimed at battling diseases with a mix of data and life...
Broad Institute
January 15, 2021
/PRNewswire/ -- Multimedia resources About Eric Lander: Director's page including science, public policy, and media About Eric Lander: Biographical information...
Conor Hale
January 11, 2021
Verily and the Broad Institute of MIT and Harvard hope to dramatically boost the reach of their open-source biomedical research platform, through a new partnership with Microsoft.
January 11, 2021
On Monday, Broad Institute of MIT and Harvard, Verily, an Alphabet company, and Microsoft Corp. announced a strategic partnership to accelerate new innovations in biomedicine through the Terra platform. Terra, originally developed by Verily and the Broad Institute, is a secure, scalable, open-source platform for biomedical researchers to access data, run analysis tools and collaborate. Terra is actively used by thousands of researchers every month to analyze data from millions of particip...
Will Knight
December 11, 2020
We reduce test results to "positive" or "negative." Some experts think patients, and the community, would be better served by a more nuanced approach.
John Hewitt
December 7, 2020
One of the most hotly contested issues in biology, or at least in mitochondrial biology, is determining which proteins can get into mitochondria. Having this kind of access essentially means a protein maintains a residence in one or more of several distinct mitochondrial compartments. These places include the matrix, the inner membrane, the intermembrane space, the outer membrane and the most nebulous listing of them all--an association with the outer membrane. Typically, it is this location that draws the biggest controversy.
Alex Keown
November 20, 2020
Biopharma and life sciences companies strengthen their leadership teams and boards with these Movers & Shakers.
Broad Institute
November 18, 2020
/PRNewswire/ -- The Broad Institute is expanding its Cancer Dependency Map (DepMap) Consortium, an academic-industrial partnership program that was first...
The Economist
October 7, 2020
The Economist
For the first time, an all-female science team is honoured
Angus Liu
June 4, 2020
Recessive hearing loss can be treated with cochlear implants, but they can't correct the underlying biological cause of deafness. A team co-led by David Liu at the Broad Institute believes genetic base editing might offer a solution, and the method has shown promise in mice.
Nick Paul
May 11, 2020
Roche has named Aviv Regev as the new head of Genentech research and early development (gRED). Regev, who currently works at the Broad Institute, will take over as head of gRED when Michael Varney retires at the end of July.
Joe Dwinell
April 18, 2020
Boston Herald
Biogen, home to the first super-spreading coronavirus outbreak in Massachusetts, is asking infected employees to give blood for a landmark COVID-19 study one researcher is calling part of a "Data Renaissance."
Jim Daley
January 20, 2020
Scientific American
Scientific American is the essential guide to the most awe-inspiring advances in science and technology, explaining how they change our understanding of the world and shape our lives.
December 3, 2019
Seattle-based Cyrus Biotechnology says it'll collaborate with the Broad Institute of MIT and Harvard on ways to optimize CRISPR gene-editing techniques for use in developing novel human therapeutics. CRISPR has revolutionized genetics by making it easier to modify the DNA coding in the genome, but
October 20, 2019
Sky News
A mobile "counter-drone" unit with technology to track down and interfere with the devices will be set up to respond to incidents.
Fink Densford
February 13, 2019
The Medical Device Business Journal -- Medical Device News & Articles | MassDevice
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