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US Patent 12092642 Systems and methods for biomolecule quantitation

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 US Patent 12092642 Systems and methods for biomolecule quantitation

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Patent abstract

Systems and methods for obtaining qualitative or quantitative measurements of proteoforms of polypeptides are described. The described methods include measurements of affinity reagent binding on single-molecule polypeptide arrays to distinguish between polypeptide isoforms. The described methods may provide high resolution quantitative comparisons of proteoforms with very low copy numbers.

Infobox
Is a
Patent
Patent
0
Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
0
Patent Number
120926420
Patent Inventor Names
Gregory Kapp0
Jarrett D. Egertson0
Parag Mallick0
Date of Patent
September 17, 2024
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Patent Application Number
175795760
Date Filed
January 19, 2022
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Patent Citations
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US Patent 7306904 Methods and kits for proximity probing
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US Patent 7351528 Probing of specific nucleic acids
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US Patent 7855054 Multiplexed analyses of test samples
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US Patent 7964356 Method for generating aptamers with improved off-rates
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US Patent 8013134 Kit for proximity probing with multivalent proximity probes
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US Patent 8222047 Ultra-sensitive detection of molecules on single molecule arrays
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US Patent 8236574 Ultra-sensitive detection of molecules or particles using beads or other capture objects
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US Patent 8268554 Method for analyte detection using proximity probes
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US Patent 8404830 Method for generating aptamers with improved off-rates
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US Patent 8415171 Methods and systems for extending dynamic range in assays for the detection of molecules or particles
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US Patent 11203612 Methods of generating nanoarrays and microarrays
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US Patent 8945830 Multiplexed analyses of test samples
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US Patent 8975026 Method for generating aptamers with improved off-rates
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US Patent 8975388 Method for generating aptamers with improved off-rates
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US Patent 9163056 5-position modified pyrimidines and their use
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US Patent 9395359 Methods and arrays for target analyte detection and determination of target analyte concentration in solution
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US Patent 9404919 Multiplexed analyses of test samples
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US Patent 9625469 Identifying peptides at the single molecule level
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US Patent 9678068 Ultra-sensitive detection of molecules using dual detection methods
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US Patent 9777315 Exonuclease enabled proximity extension assays
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US Patent 9926566 Multiaptamer target detection
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US Patent 9938314 Cytidine-5-carboxamide modified nucleotide compositions and methods related thereto
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US Patent 10221207 5-position modified pyrimidines and their use
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US Patent 10221421 Post-selec modification methods
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US Patent 10239908 Cytidine-5-carboxamide modified nucleotide compositions and methods related thereto
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US Patent 10316321 Method for generating aptamers with improved off-rates
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US Patent 10392621 Multiaptamer target detection
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US Patent 10473654 Methods of assaying proteins
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US Patent 10545153 Single molecule peptide sequencing
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Patent Primary Examiner
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Christopher M Gross
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