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US Patent 8945830 Multiplexed analyses of test samples

Patent 8945830 was granted and assigned to SomaLogic, Inc. on February, 2015 by the United States Patent and Trademark Office.

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Patent
Patent

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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
Patent Number
8945830
Patent Inventor Names
Daniel T. Nieuwlandt5
Bruce Eaton5
Daniel J. Schneider5
Dominic Zichi5
James R. Heil5
Larry Gold5
Sheri K. Wilcox5
Todd Gander5
Date of Patent
February 3, 2015
Patent Application Number
12859930
Date Filed
August 20, 2010
Patent Citations Received
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US Patent 11760997 Systems and methods for biomolecule retention
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US Patent 12071618 Systems and methods for biomolecule retention
1
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US Patent 12092642 Systems and methods for biomolecule quantitation
2
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US Patent 11935311 Methods and systems for computational decoding of biological, chemical, and physical entities
3
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US Patent 11768201 Methods of assaying proteins
‌
US Patent 11912990 Systems and methods for biomolecule retention
4
Patent Primary Examiner
‌
Teresa E Strzelecka
Patent abstract

The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. In one embodiment, a test sample is contacted with an aptamer that includes a tag and has a specific affinity for a target molecule. An aptamer affinity complex that includes an aptamer bound to its target molecule is allowed to form. If the test sample contains the target molecule, an aptamer affinity complex will generally form in the test sample. The aptamer affinity complex is optionally converted to an aptamer covalent complex that includes an aptamer covalently bound to its target molecule. The aptamer affinity complex (or optional aptamer covalent complex) can then be detected and/or quantified using any of a variety of methods known to one skilled in the art, including using a solid support, using mass spectrometry, and using quantitative polymerase chain reaction (Q-PCR).

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