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US Patent 8404830 Method for generating aptamers with improved off-rates

Patent 8404830 was granted and assigned to SomaLogic, Inc. on March, 2013 by the United States Patent and Trademark Office.

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Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Chris Bock1

Bruce Eaton1

Daniel J. Schneider1

Dominic Zichi1

Larry Gold1

Sheri K. Wilcox1

Date of Patent

March 26, 2013

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Patent Application Number

129692391

Date Filed

December 15, 2010

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Patent Citations Received

US Patent 11760997 Systems and methods for biomolecule retention

US Patent 11935311 Methods and systems for computational decoding of biological, chemical, and physical entities

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US Patent 11768201 Methods of assaying proteins

US Patent 11912990 Systems and methods for biomolecule retention

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US Patent 12092642 Systems and methods for biomolecule quantitation

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US Patent 12071618 Systems and methods for biomolecule retention

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Patent Primary Examiner

Lawrence E Crane

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Patent abstract

The present disclosure is directed to the field of nucleic acid chemistry, specifically to 5-position modified uridines, as well as, oligonucleotides comprising said 5-position modified uridines. The present disclosure describes methods for producing aptamers comprising said 5-position modified uridines that are capable of binding to target molecules.

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