Patent 12023378 was granted and assigned to Hoffmann-La Roche Limited on July, 2024 by the United States Patent and Trademark Office.
Herein is reported a conjugate comprising an antigen and an antibody that specifically binds to the antigen wherein a covalent bond is formed between the antigen and an amino acid residue in the CDR2 of the antibody, an antibody comprising a cysteine residue at amino acid position 53 (according to Kabat) in the heavy chain CDR2 and uses thereof.