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US Patent 12023378 Covalently linked antigen-antibody conjugates

Patent 12023378 was granted and assigned to Hoffmann-La Roche Limited on July, 2024 by the United States Patent and Trademark Office.

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Contents

Is a
Patent
Patent
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Patent attributes

Patent Applicant
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Hoffmann-La Roche Limited
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Current Assignee
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Hoffmann-La Roche Limited
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
120233780
Patent Inventor Names
Sebastian Dziadek0
Michael Grote0
Guy Georges0
Ulrich Brinkmann0
Stefan Dengl0
Eike Hoffmann0
Alexander Haas0
Joerg Benz0
Date of Patent
July 2, 2024
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Patent Application Number
166674640
Date Filed
October 29, 2019
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Patent Citations
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US Patent 7041870 Transgenic transchromosomal rodents for making human antibodies
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US Patent 6881536 Particle based electrochemiluminescent assays
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US Patent 6897044 Production of tetravalent antibodies
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US Patent 6946292 Cells producing antibody compositions with increased antibody dependent cytotoxic activity
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US Patent 8907069 Complex of bi-specific antibody and digoxigenin conjugated to a therapeutic or diagnostic agent
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US Patent 8945867 Process for producing polypeptide
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US Patent 9050375 Bi-specific digoxigenin binding antibodies
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US Patent 9765153 Anti-biotin antibodies and methods of use
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Patent Primary Examiner
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Phuong Huynh
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CPC Code
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C07K 16/40
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C07K 16/44
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C07K 16/468
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C07K 2317/24
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C07K 2317/31
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C07K 2317/40
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C07K 2317/55
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C07K 2317/565
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Patent abstract

Herein is reported a conjugate comprising an antigen and an antibody that specifically binds to the antigen wherein a covalent bond is formed between the antigen and an amino acid residue in the CDR2 of the antibody, an antibody comprising a cysteine residue at amino acid position 53 (according to Kabat) in the heavy chain CDR2 and uses thereof.

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