Is a
Patent attributes
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Brian E. Toki0
Peter D. Senter0
Svetlana O. Doronina0
Date of Patent
March 3, 2009
0Patent Application Number
109833400
Date Filed
November 5, 2004
0Patent Citations Received
...
Patent Primary Examiner
Patent abstract
Auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF), were prepared and attached to Ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo.
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