Is a
Patent attributes
Patent Applicant
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Stephen T. Schlachter0
Jonas Grina0
Hanbiao Yang0
Paul Wehn0
John A. Josey0
Eli M. Wallace0
Rui Xu0
Bin Wang0
...
Date of Patent
April 30, 2024
0Patent Application Number
175921080
Date Filed
February 3, 2022
0Patent Citations
Patent Primary Examiner
Patent abstract
The present disclosure relates to HIF-2α inhibitors and methods of making and using them for treating cancer. Certain compounds were potent in HIF-2α scintillation proximity assay, luciferase assay, and VEGF ELISA assay, and led to tumor size reduction and regression in 786-O xenograft bearing mice in vivo.
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