Is a
Patent attributes
Patent Applicant
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Darryl David Dixon0
Bin Wang0
Paul Wehn0
Rui Xu0
Stephen T. Schlachter0
Eli M. Wallace0
Hanbiao Yang0
James P. Rizzi0
...
Date of Patent
March 6, 2018
0Patent Application Number
149057760
Date Filed
September 5, 2014
0Patent Citations Received
Patent Primary Examiner
Patent abstract
The present disclosure relates to HIF-2α inhibitors and methods of making and using them for treating cancer. Certain compounds were potent in HIF-2α scintillation proximity assay, luciferase assay, and VEGF ELISA assay, and led to tumor size reduction and regression in 786-O xenograft bearing mice in vivo.
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