Is a
Patent attributes
Patent Applicant
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Rui Xu0
Jonas Grina0
Paul Wehn0
Stephen T. Schlachter0
Bin Wang0
Darryl David Dixon0
Eli M. Wallace0
Hanbiao Yang0
...
Date of Patent
December 4, 2018
0Patent Application Number
158053900
Date Filed
November 7, 2017
0Patent Citations Received
Patent Primary Examiner
Patent abstract
The present disclosure relates to HIF-2α inhibitors and methods of making and using them for treating cancer. Certain compounds were potent in HIF-2α scintillation proximity assay, luciferase assay, and VEGF ELISA assay, and led to tumor size reduction and regression in 786-O xenograft bearing mice in vivo.
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