Patent 9517276 was granted and assigned to CytomX Therapeutics on December, 2016 by the United States Patent and Trademark Office.
The invention relates generally to compositions and methods for conjugating antibodies and activatable antibodies, and methods of partially reducing antibodies and/or activatable antibodies prior to conjugation, e.g., thiol-based conjugation, with an agent, e.g., a therapeutic and/or diagnostic agent.