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US Patent 11992528 Compositions and methods for conjugating activatable antibodies

Patent 11992528 was granted and assigned to CytomX Therapeutics on May, 2024 by the United States Patent and Trademark Office.

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Is a
Patent
Patent
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Patent attributes

Patent Applicant
CytomX Therapeutics
CytomX Therapeutics
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Current Assignee
CytomX Therapeutics
CytomX Therapeutics
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
119925280
Patent Inventor Names
Shweta Singh0
Luc Roland Desnoyers0
Henry Bernard Lowman0
Tony W. Liang0
Andrei William Konradi0
Date of Patent
May 28, 2024
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Patent Application Number
172270040
Date Filed
April 9, 2021
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Patent Citations
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US Patent 7837980 Partially loaded antibodies and methods of their conjugation
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US Patent 8293685 Methods for enhancing bacterial cell display of proteins and peptides
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US Patent 8309094 Antibody-drug conjugates
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US Patent 8586049 Antibody-drug conjugates
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US Patent 9517276 Compositions and methods for conjugating activatable antibodies
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US Patent 8809504 Inhibitor which is deactivatable by a reagent produced by a target cell
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US Patent 6884869 Pentapeptide compounds and uses related thereto
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US Patent 7465790 Therapeutic antibodies
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...
Patent Primary Examiner
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Phuong Huynh
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Patent abstract

The invention relates generally to compositions and methods for conjugating antibodies and activatable antibodies, and methods of partially reducing antibodies and/or activatable antibodies prior to conjugation, e.g., thiol-based conjugation, with an agent, e.g., a therapeutic and/or diagnostic agent.

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