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US Patent 7498302 Disulfide prodrugs and linkers and stabilizers useful therefor

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Is a

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Patent attributes

Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Oliver L. Saunders0

Sharon Elaine Boyd0

Thomas J. Lobl0

Valeri Martichonok0

Zhi-Hong Li0

David J. King0

Guoxian Wu0

Howard P. Ng0

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Date of Patent

March 3, 2009

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Patent Application Number

111339700

Date Filed

May 20, 2005

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Patent Citations Received

US Patent 12129309 Heterodimeric antibodies that bind CD3 and CD38

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US Patent 11788066 Antibody conjugates and methods of making and using the same

US Patent 11840579 Bispecific antibodies that bind to CD38 and CD3

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US Patent 11859012 Heterodimeric antibodies that bind CD3 and GPC3

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US Patent 11919956 Heterodimeric antibodies that bind prostate specific membrane antigen (PSMA) and CD3

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US Patent 11945880 Heterodimeric antibodies that bind CD3 and tumor antigens

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Patent Primary Examiner

Cecilia J. Tsang

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Patent abstract

The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.

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