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US Patent 11859012 Heterodimeric antibodies that bind CD3 and GPC3

Patent 11859012 was granted and assigned to Xencor on January, 2024 by the United States Patent and Trademark Office.

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Contents

Is a
Patent
Patent
0

Patent attributes

Patent Applicant
Xencor
Xencor
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Current Assignee
Xencor
Xencor
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
118590120
Patent Inventor Names
Matthew J. Bernett0
Nargess Hassanzadeh-Kiabi0
Katrina Bykova0
Rajat Varma0
Alex Nisthal0
Date of Patent
January 2, 2024
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Patent Application Number
176920450
Date Filed
March 10, 2022
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Patent Citations
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US Patent 7276497 Cytotoxic agents comprising new maytansinoids
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US Patent 6884869 Pentapeptide compounds and uses related thereto
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US Patent 6989452 Disulfide prodrugs and linkers and stabilizers useful therefor
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US Patent 7087600 Peptidyl prodrugs and linkers and stabilizers useful therefor
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US Patent 7112324 CD 19×CD3 specific polypeptides and uses thereof
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US Patent 7129261 Cytotoxic agents
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US Patent 8409568 Mutant antibody Fc domains and fusion proteins thereof
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US Patent 8592562 Method for making antibody Fc-heterodimeric molecules using electrostatic steering effects
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...
Patent Primary Examiner
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Adam Weidner
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CPC Code
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A61P 35/00
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C07K 16/2809
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C07K 16/468
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Patent abstract

Provided herein are novel GPC3 binding domains, and antibodies that include such GPC3 binding domains (e.g., anti-GPC3×anti-CD3). Also provided herein are methods of using such antibodies for the treatment of GPC3-associated cancers.

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