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US Patent 11919956 Heterodimeric antibodies that bind prostate specific membrane antigen (PSMA) and CD3

Patent 11919956 was granted and assigned to Xencor on March, 2024 by the United States Patent and Trademark Office.

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Is a
Patent
Patent
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Patent attributes

Patent Applicant
Xencor
Xencor
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Current Assignee
Xencor
Xencor
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
119199560
Patent Inventor Names
John R. Desjarlais0
Michael Hedvat0
Matthew Adam Dragovich0
Alex Nisthal0
Date of Patent
March 5, 2024
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Patent Application Number
173213250
Date Filed
May 14, 2021
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Patent Citations
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US Patent 7303749 Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
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US Patent 7368565 Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents
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US Patent 7498302 Disulfide prodrugs and linkers and stabilizers useful therefor
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US Patent 7507420 Peptidyl prodrugs and linkers and stabilizers useful therefor
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US Patent 7517903 Cytotoxic compounds and conjugates
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US Patent 7601354 Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
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US Patent 7642228 Method for making heteromultimeric polypeptides
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...
Patent Primary Examiner
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Laura B Goddard
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Patent abstract

Provided herein are novel antigen binding domains and antibodies (e.g., heterodimeric antibodies) that bind Prostate Specific Membrane Antigen (PSMA). In exemplary embodiments, the anti-PSMA antibodies also bind CD3. Such antibodies that bind PSMA and CD3 are useful, for example in the treatment of PSMA-related cancer.

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