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US Patent 7208157 Proteolysis targeting chimeric pharmaceutical

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Contents

Is a
Patent
Patent
0

Patent attributes

Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
0
Patent Number
72081570
Patent Inventor Names
Craig Crews0
Kathleen M. Sakamoto0
Raymond J. Dashaies0
Date of Patent
April 24, 2007
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Patent Application Number
102992030
Date Filed
November 18, 2002
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Patent Citations Received
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US Patent 12091411 IRAK degraders and uses thereof
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0
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US Patent 12076405 Heterocyclic degronimers for target protein degradation
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US Patent 12077509 Compounds and methods for the targeted degradation of androgen receptor
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US Patent 12077555 STAT degraders and uses thereof
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US Patent 12091397 Dihydroquinolinones for medical treatment
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US Patent 11679109 SMARCA degraders and uses thereof
0
...
Patent Primary Examiner
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Stacy B. Chen
0
Patent abstract

The present invention is based on the discovery of a composition that provides targeted ubiquitination. Specifically the composition contains a ubiquitin pathway protein binding moiety which recognizes a ubiquitin pathway protein and a targeting moiety which recognizes a target protein. In addition, the present invention provides libraries of compositions, where each composition contains a ubiquitin pathway protein binding moiety and a member of a molecular library. The libraries of the present invention can be used to identify proteins involved in a predetermined function of cells.

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