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US Patent 12076405 Heterocyclic degronimers for target protein degradation

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Contents

Is a
Patent
Patent
0

Patent attributes

Patent Applicant
C4 Therapeutics
C4 Therapeutics
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
120764050
Patent Inventor Names
Andrew J. Phillips0
Yanke Liang0
Minsheng He0
James A. Henderson0
Christopher G. Nasveschuk0
Ryan E. Michael0
Mark E. Fitzgerald0
Date of Patent
September 3, 2024
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Patent Application Number
171644460
Date Filed
February 1, 2021
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Patent Citations
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US Patent 10351568 Compositions and methods for enhancing proteasome activity
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US Patent 10414755 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
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US Patent 10905768 Heterocyclic degronimers for target protein degradation
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US Patent 10646575 Heterocyclic degronimers for target protein degradation
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US Patent 7041298 Proteolysis targeting chimeric pharmaceutical
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US Patent 7208157 Proteolysis targeting chimeric pharmaceutical
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US Patent 9125915 Antitumor agent
0
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US Patent 9249161 Bromodomain inhibitors and uses thereof
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Patent Primary Examiner
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Joseph R Kosack
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CPC Code
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C07D 401/04
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A61P 35/00
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A61P 37/00
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C07D 403/04
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A61K 47/554
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A61K 31/55
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A61K 31/547
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A61K 31/454
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Patent abstract

This invention provides heterocyclic compounds that bind to E3 Ubiquitin Ligase (typically through cereblon) (“Degrons”), which can be used as is or linked to a Targeting Ligand for a selected Target Protein for therapeutic purposes and methods of use and compositions thereof as well as methods for their preparation.

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