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US Patent 7041298 Proteolysis targeting chimeric pharmaceutical

Patent 7041298 was granted and assigned to California Institute of Technology on May, 2006 by the United States Patent and Trademark Office.

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Patent
Patent
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Patent attributes

Current Assignee
California Institute of Technology
California Institute of Technology
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
70412980
Patent Inventor Names
Craig Crews0
Kathleen M. Sakamoto0
Raymond J. Deshaies0
Date of Patent
May 9, 2006
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Patent Application Number
099534730
Date Filed
September 10, 2001
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Patent Citations Received
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US Patent 12091411 IRAK degraders and uses thereof
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0
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US Patent 12076405 Heterocyclic degronimers for target protein degradation
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US Patent 12077509 Compounds and methods for the targeted degradation of androgen receptor
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US Patent 12077555 STAT degraders and uses thereof
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US Patent 12091397 Dihydroquinolinones for medical treatment
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US Patent 11834460 Imide-based modulators of proteolysis and associated methods of use
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...
Patent Primary Examiner
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Ulrike Winkler
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Patent abstract

The present invention is based on the discovery of a composition that provides targeted ubiquitination. Specifically the composition contains an ubiquitin pathway protein binding moiety which recognizes an ubiquitin pathway protein and a targeting moiety which recognizes a target protein. In addition, the present invention provides libraries of compositions, where each composition contains an ubiquitin pathway protein binding moiety and a member of a molecular library. The libraries of the present invention can be used to identify proteins involved in a predetermined function of cells.

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