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US Patent 6878515 Ultrasensitive immunoassays

Patent 6878515 was granted and assigned to LG on April, 2005 by the United States Patent and Trademark Office.

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Contents

Is a
Patent
Patent
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Patent attributes

Patent Applicant
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Current Assignee
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
68785150
Patent Inventor Names
Ulf Landegren0
Date of Patent
April 12, 2005
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Patent Application Number
089813100
Date Filed
June 14, 1996
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Patent Citations Received
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US Patent 11999801 Multispecific antibodies
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US Patent 11965213 Methods of detecting spatial heterogeneity of a biological sample
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US Patent 12105084 Nucleic acid linked immune-sandwich assay (NULISA)
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US Patent 11840687 Nucleic acid library methods
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US Patent 11859178 Nucleic acid library methods
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US Patent 11866770 Spatially encoded biological assays
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US Patent 11913952 Methods for detecting peptide/MHC/TCR binding
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Patent Primary Examiner
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Lynette R. F. Smith
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Patent abstract

The present invention relates to an immunological test kit and immunoassay using a first immobilized antibody having affinity for a specific antigen. The invention is characterized by a second and third antibody being specific for different determinants of the antigen and modified with cross-linkable oligonucleotides. For detection, the oligonucleotides are amplified, whereby only such oligonucleotides will be amplified which have been cross-linked to each other. In this way unspecific background is avoided and detection is possible down to single molecules.

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