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US Patent 11866770 Spatially encoded biological assays

Patent 11866770 was granted and assigned to PROGNOSYS BIOSCIENCES, INC. on January, 2024 by the United States Patent and Trademark Office.

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Patent attributes

Patent Applicant

PROGNOSYS BIOSCIENCES, INC.

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Current Assignee

PROGNOSYS BIOSCIENCES, INC.

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Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Mark S. Chee0

Date of Patent

January 9, 2024

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Patent Application Number

183247270

Date Filed

May 26, 2023

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Patent Citations

US Patent 6875572 Nucleic acid detection assays

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US Patent 6911345 Methods and apparatus for analyzing polynucleotide sequences

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US Patent 6913881 Methods and compositions for detecting target sequences

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US Patent 6913921 Rapid cell block embedding method and apparatus

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Patent Citations Received

US Patent 11970739 Multiplex capture of gene and protein expression from a biological sample

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US Patent 11981958 Methods for spatial analysis using DNA capture

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US Patent 11981960 Spatial analysis utilizing degradable hydrogels

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US Patent 12071655 Methods, compositions, kits, and systems for enhancing analyte capture for spatial analysis

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US Patent 12076701 Capturing oligonucleotides in spatial transcriptomics

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US Patent 12110541 Methods for preparing high-resolution spatial arrays

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US Patent 12129516 Quantitative and automated permeabilization performance evaluation for spatial transcriptomics

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Patent Primary Examiner

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Patent abstract

The present invention provides assays and assay systems for use in spatially encoded biological assays. The invention provides an assay system comprising an assay capable of high levels of multiplexing where reagents are provided to a biological sample in defined spatial patterns; instrumentation capable of controlled delivery of reagents according to the spatial patterns; and a decoding scheme providing a readout that is digital in nature.

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